Chronic cocaine produces decreases in N/OFQ peptide levels in select rat brain regions

Patrizia Romualdi; Manuela Di Benedetto; Claudio D'Addario; Stephanie L. Collins; Dean Wade; Sanzio Candeletti; Sari Izenwasser

Chronic cocaine produces decreases in N/OFQ peptide levels in select rat brain regions

Patrizia Romualdi, Manuela Di Benedetto, Claudio D'Addario, Stephanie L. Collins, Dean Wade, Sanzio Candeletti, Sari Izenwasser

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The interaction of opioids and stimulants is well established; however, the mechanisms that underlie the role that opioid receptors play in psychostimulant action are not. Nociceptin/orphaninFQ (N/OFQ), the endogenous agonist at NOP receptors, attenuates the behavioral effects of cocaine. The effects of cocaine on N/OFQ were examined in rats using immunoautoradiographic and RIA techniques. Chronic administration of cocaine decreased N/OFQ in medial regions of the caudate putamen, the nucleus accumbens shell, and the substantia nigra. These studies show that N/OFQ levels are altered by treatment with cocaine. Furthermore, the changes in N/OFQ parallel those seen for κ-opioid receptors, suggesting that the interactions between cocaine and these systems might be similar.

Original language	English (US)
Pages (from-to)	159-164
Number of pages	6
Journal	Journal of Molecular Neuroscience
Volume	31
Issue number	2
State	Published - Feb 2007

Keywords

Caudate putamen
Cocaine
N/OFQ
Nucleus accumbens
Opioid
Substantia nigra

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry
Genetics

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title = "Chronic cocaine produces decreases in N/OFQ peptide levels in select rat brain regions",

abstract = "The interaction of opioids and stimulants is well established; however, the mechanisms that underlie the role that opioid receptors play in psychostimulant action are not. Nociceptin/orphaninFQ (N/OFQ), the endogenous agonist at NOP receptors, attenuates the behavioral effects of cocaine. The effects of cocaine on N/OFQ were examined in rats using immunoautoradiographic and RIA techniques. Chronic administration of cocaine decreased N/OFQ in medial regions of the caudate putamen, the nucleus accumbens shell, and the substantia nigra. These studies show that N/OFQ levels are altered by treatment with cocaine. Furthermore, the changes in N/OFQ parallel those seen for κ-opioid receptors, suggesting that the interactions between cocaine and these systems might be similar.",

keywords = "Caudate putamen, Cocaine, N/OFQ, Nucleus accumbens, Opioid, Substantia nigra",

author = "Patrizia Romualdi and {Di Benedetto}, Manuela and Claudio D'Addario and Collins, {Stephanie L.} and Dean Wade and Sanzio Candeletti and Sari Izenwasser",

year = "2007",

month = feb,

language = "English (US)",

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journal = "Journal of Molecular Neuroscience",

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T1 - Chronic cocaine produces decreases in N/OFQ peptide levels in select rat brain regions

AU - Romualdi, Patrizia

AU - Di Benedetto, Manuela

AU - D'Addario, Claudio

AU - Collins, Stephanie L.

AU - Wade, Dean

AU - Candeletti, Sanzio

AU - Izenwasser, Sari

PY - 2007/2

Y1 - 2007/2

N2 - The interaction of opioids and stimulants is well established; however, the mechanisms that underlie the role that opioid receptors play in psychostimulant action are not. Nociceptin/orphaninFQ (N/OFQ), the endogenous agonist at NOP receptors, attenuates the behavioral effects of cocaine. The effects of cocaine on N/OFQ were examined in rats using immunoautoradiographic and RIA techniques. Chronic administration of cocaine decreased N/OFQ in medial regions of the caudate putamen, the nucleus accumbens shell, and the substantia nigra. These studies show that N/OFQ levels are altered by treatment with cocaine. Furthermore, the changes in N/OFQ parallel those seen for κ-opioid receptors, suggesting that the interactions between cocaine and these systems might be similar.

AB - The interaction of opioids and stimulants is well established; however, the mechanisms that underlie the role that opioid receptors play in psychostimulant action are not. Nociceptin/orphaninFQ (N/OFQ), the endogenous agonist at NOP receptors, attenuates the behavioral effects of cocaine. The effects of cocaine on N/OFQ were examined in rats using immunoautoradiographic and RIA techniques. Chronic administration of cocaine decreased N/OFQ in medial regions of the caudate putamen, the nucleus accumbens shell, and the substantia nigra. These studies show that N/OFQ levels are altered by treatment with cocaine. Furthermore, the changes in N/OFQ parallel those seen for κ-opioid receptors, suggesting that the interactions between cocaine and these systems might be similar.

KW - Caudate putamen

KW - Cocaine

KW - N/OFQ

KW - Nucleus accumbens

KW - Opioid

KW - Substantia nigra

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