Abstract
Pulmonary artery banding was performed in 8 fetal sheep at 125 days' gestation to evaluate the feasibility of fetal closed cardiac operation. At 135 days' gestation, the fetuses were delivered and the cardiac mechanics were evaluated using a modified Langendorff isolated heart preparation. Two of the 8 fetuses aborted spontaneously 2 and 7 days after operation. Six fetuses (75%) survived the 10 days after delivery. The left ventricular cardiac mechanics in the banded fetuses (group I) were compared with those in 8 control fetuses (group II). All fetal hearts in both groups displayed a significant volume-pressure relationship. The volume-pressure curve was found to be shifted upward and to the left in the fetal hearts after pulmonary artery banding. The left ventricles subjected to increased in utero preload secondary to pulmonary artery banding were capable of generating greater peak systolic and developed pressures. Because the fetal heart manifests a Starling type of preload reserve, as such, it demonstrates that the possibility exists for subsequent fetal development to be altered by intrauterine intervention.
| Original language | English |
|---|---|
| Pages (from-to) | 1409-1415 |
| Number of pages | 7 |
| Journal | The Annals of Thoracic Surgery |
| Volume | 57 |
| Issue number | 6 |
| State | Published - Jun 1 1994 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Surgery
- Cardiology and Cardiovascular Medicine
Cite this
Chronic alterations in cardiac mechanics after fetal closed heart operation. / Sandhu, Satinder K; Heckman, James L.; Balsara, Rohinton; Russo, Pierantonio A.; Dunn, Jeffrey M.
In: The Annals of Thoracic Surgery, Vol. 57, No. 6, 01.06.1994, p. 1409-1415.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic alterations in cardiac mechanics after fetal closed heart operation
AU - Sandhu, Satinder K
AU - Heckman, James L.
AU - Balsara, Rohinton
AU - Russo, Pierantonio A.
AU - Dunn, Jeffrey M.
PY - 1994/6/1
Y1 - 1994/6/1
N2 - Pulmonary artery banding was performed in 8 fetal sheep at 125 days' gestation to evaluate the feasibility of fetal closed cardiac operation. At 135 days' gestation, the fetuses were delivered and the cardiac mechanics were evaluated using a modified Langendorff isolated heart preparation. Two of the 8 fetuses aborted spontaneously 2 and 7 days after operation. Six fetuses (75%) survived the 10 days after delivery. The left ventricular cardiac mechanics in the banded fetuses (group I) were compared with those in 8 control fetuses (group II). All fetal hearts in both groups displayed a significant volume-pressure relationship. The volume-pressure curve was found to be shifted upward and to the left in the fetal hearts after pulmonary artery banding. The left ventricles subjected to increased in utero preload secondary to pulmonary artery banding were capable of generating greater peak systolic and developed pressures. Because the fetal heart manifests a Starling type of preload reserve, as such, it demonstrates that the possibility exists for subsequent fetal development to be altered by intrauterine intervention.
AB - Pulmonary artery banding was performed in 8 fetal sheep at 125 days' gestation to evaluate the feasibility of fetal closed cardiac operation. At 135 days' gestation, the fetuses were delivered and the cardiac mechanics were evaluated using a modified Langendorff isolated heart preparation. Two of the 8 fetuses aborted spontaneously 2 and 7 days after operation. Six fetuses (75%) survived the 10 days after delivery. The left ventricular cardiac mechanics in the banded fetuses (group I) were compared with those in 8 control fetuses (group II). All fetal hearts in both groups displayed a significant volume-pressure relationship. The volume-pressure curve was found to be shifted upward and to the left in the fetal hearts after pulmonary artery banding. The left ventricles subjected to increased in utero preload secondary to pulmonary artery banding were capable of generating greater peak systolic and developed pressures. Because the fetal heart manifests a Starling type of preload reserve, as such, it demonstrates that the possibility exists for subsequent fetal development to be altered by intrauterine intervention.
UR - http://www.scopus.com/inward/record.url?scp=0028365111&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028365111&partnerID=8YFLogxK
M3 - Article
C2 - 8010781
AN - SCOPUS:0028365111
VL - 57
SP - 1409
EP - 1415
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
SN - 0003-4975
IS - 6
ER -