Chronic alterations in cardiac mechanics after fetal closed heart operation

Satinder K Sandhu, James L. Heckman, Rohinton Balsara, Pierantonio A. Russo, Jeffrey M. Dunn

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Pulmonary artery banding was performed in 8 fetal sheep at 125 days' gestation to evaluate the feasibility of fetal closed cardiac operation. At 135 days' gestation, the fetuses were delivered and the cardiac mechanics were evaluated using a modified Langendorff isolated heart preparation. Two of the 8 fetuses aborted spontaneously 2 and 7 days after operation. Six fetuses (75%) survived the 10 days after delivery. The left ventricular cardiac mechanics in the banded fetuses (group I) were compared with those in 8 control fetuses (group II). All fetal hearts in both groups displayed a significant volume-pressure relationship. The volume-pressure curve was found to be shifted upward and to the left in the fetal hearts after pulmonary artery banding. The left ventricles subjected to increased in utero preload secondary to pulmonary artery banding were capable of generating greater peak systolic and developed pressures. Because the fetal heart manifests a Starling type of preload reserve, as such, it demonstrates that the possibility exists for subsequent fetal development to be altered by intrauterine intervention.

Original languageEnglish
Pages (from-to)1409-1415
Number of pages7
JournalThe Annals of Thoracic Surgery
Volume57
Issue number6
StatePublished - Jun 1 1994
Externally publishedYes

Fingerprint

Fetal Heart
Mechanics
Fetus
Pulmonary Artery
Aborted Fetus
Starlings
Pressure
Pregnancy
Fetal Development
Heart Ventricles
Sheep
Blood Pressure
Control Groups

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Sandhu, S. K., Heckman, J. L., Balsara, R., Russo, P. A., & Dunn, J. M. (1994). Chronic alterations in cardiac mechanics after fetal closed heart operation. The Annals of Thoracic Surgery, 57(6), 1409-1415.

Chronic alterations in cardiac mechanics after fetal closed heart operation. / Sandhu, Satinder K; Heckman, James L.; Balsara, Rohinton; Russo, Pierantonio A.; Dunn, Jeffrey M.

In: The Annals of Thoracic Surgery, Vol. 57, No. 6, 01.06.1994, p. 1409-1415.

Research output: Contribution to journalArticle

Sandhu, SK, Heckman, JL, Balsara, R, Russo, PA & Dunn, JM 1994, 'Chronic alterations in cardiac mechanics after fetal closed heart operation', The Annals of Thoracic Surgery, vol. 57, no. 6, pp. 1409-1415.
Sandhu, Satinder K ; Heckman, James L. ; Balsara, Rohinton ; Russo, Pierantonio A. ; Dunn, Jeffrey M. / Chronic alterations in cardiac mechanics after fetal closed heart operation. In: The Annals of Thoracic Surgery. 1994 ; Vol. 57, No. 6. pp. 1409-1415.
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