Chromosomal translocations and their role in the pathogenesis of non-Hodgkin's lymphomas

Francisco Vega, Rocio Orduz, L. Jeffrey Medeiros

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The discovery that non-Hodgkin's lymphomas are monoclonal and that recurrent chromosomal translocations are involved in their pathogenesis has greatly revolutionised their diagnosis and improved our understanding of these diseases. In the last decades, many genes deregulated by such recurrent chromosomal translocations have been identified. However, we have also learned that these genetic alterations are apparently insufficient, in themselves, to cause neoplastic cell transformation and that more complex genetic events must be involved. This review examines the involved genes in chromosomal translocations and current evidence and postulated mechanisms for their role in the pathogenesis of non-Hodgkin's lymphomas.

Original languageEnglish (US)
Pages (from-to)397-409
Number of pages13
JournalPathology
Volume34
Issue number5
DOIs
StatePublished - Oct 2002
Externally publishedYes

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Keywords

  • Chromosomal translocations
  • Gene expression
  • Molecular genetics
  • Non-Hodgkin's lymphomas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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