Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp 11.2

D. J. Barrett, J. B. Bateman, R. S. Sparkes, T. Mohandas, I. Klisak, George Inana

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Gyrate atrophy is a hereditary chorioretinal degeneration associated with a deficiency of ornithine aminotransferase (OAT). By means of a complementary DNA clone encoding human OAT, the OAT gene sequences were mapped by somatic cell hybrids and in situ hybridization to human chromosome regions 10q26 and Xp11.2. A review of 80 biochemically confirmed cases of gyrate atrophy confirmed the autosomal recessive inheritance of this disease and supported the presence of a functional OAT gene on chromosome 10. Interestingly, the X chromosomes OAT gene sequences (Xp11.2) map to the same region as L1.28 (Xp11.0-p11.3), a marker closely linked to X-linked recessive retinitis pigmentosa.

Original languageEnglish
Pages (from-to)1037-1042
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume28
Issue number7
StatePublished - Aug 18 1987
Externally publishedYes

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Ornithine-Oxo-Acid Transaminase
Gyrate Atrophy
Genes
Chromosomes, Human, Pair 10
Retinitis Pigmentosa
Hybrid Cells
Human Chromosomes
X Chromosome
In Situ Hybridization
Complementary DNA
Clone Cells

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp 11.2. / Barrett, D. J.; Bateman, J. B.; Sparkes, R. S.; Mohandas, T.; Klisak, I.; Inana, George.

In: Investigative Ophthalmology and Visual Science, Vol. 28, No. 7, 18.08.1987, p. 1037-1042.

Research output: Contribution to journalArticle

Barrett, DJ, Bateman, JB, Sparkes, RS, Mohandas, T, Klisak, I & Inana, G 1987, 'Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp 11.2', Investigative Ophthalmology and Visual Science, vol. 28, no. 7, pp. 1037-1042.
Barrett, D. J. ; Bateman, J. B. ; Sparkes, R. S. ; Mohandas, T. ; Klisak, I. ; Inana, George. / Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp 11.2. In: Investigative Ophthalmology and Visual Science. 1987 ; Vol. 28, No. 7. pp. 1037-1042.
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