Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp 11.2

D. J. Barrett; J. B. Bateman; R. S. Sparkes; T. Mohandas; I. Klisak; G. Inana

Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp 11.2

D. J. Barrett, J. B. Bateman, R. S. Sparkes, T. Mohandas, I. Klisak, G. Inana

Research output: Contribution to journal › Article › peer-review

Abstract

Gyrate atrophy is a hereditary chorioretinal degeneration associated with a deficiency of ornithine aminotransferase (OAT). By means of a complementary DNA clone encoding human OAT, the OAT gene sequences were mapped by somatic cell hybrids and in situ hybridization to human chromosome regions 10q26 and Xp11.2. A review of 80 biochemically confirmed cases of gyrate atrophy confirmed the autosomal recessive inheritance of this disease and supported the presence of a functional OAT gene on chromosome 10. Interestingly, the X chromosomes OAT gene sequences (Xp11.2) map to the same region as L1.28 (Xp11.0-p11.3), a marker closely linked to X-linked recessive retinitis pigmentosa.

Original language	English (US)
Pages (from-to)	1037-1042
Number of pages	6
Journal	Investigative Ophthalmology and Visual Science
Volume	28
Issue number	7
State	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

Access to Document

Fingerprint Dive into the research topics of 'Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp 11.2'. Together they form a unique fingerprint.

Cite this

@article{cde7c0a2de4f441c848f75307b8d59c1,

title = "Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp 11.2",

abstract = "Gyrate atrophy is a hereditary chorioretinal degeneration associated with a deficiency of ornithine aminotransferase (OAT). By means of a complementary DNA clone encoding human OAT, the OAT gene sequences were mapped by somatic cell hybrids and in situ hybridization to human chromosome regions 10q26 and Xp11.2. A review of 80 biochemically confirmed cases of gyrate atrophy confirmed the autosomal recessive inheritance of this disease and supported the presence of a functional OAT gene on chromosome 10. Interestingly, the X chromosomes OAT gene sequences (Xp11.2) map to the same region as L1.28 (Xp11.0-p11.3), a marker closely linked to X-linked recessive retinitis pigmentosa.",

author = "Barrett, {D. J.} and Bateman, {J. B.} and Sparkes, {R. S.} and T. Mohandas and I. Klisak and G. Inana",

year = "1987",

language = "English (US)",

volume = "28",

pages = "1037--1042",

journal = "Investigative Ophthalmology and Visual Science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "7",

}

TY - JOUR

T1 - Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp 11.2

AU - Barrett, D. J.

AU - Bateman, J. B.

AU - Sparkes, R. S.

AU - Mohandas, T.

AU - Klisak, I.

AU - Inana, G.

PY - 1987

Y1 - 1987

N2 - Gyrate atrophy is a hereditary chorioretinal degeneration associated with a deficiency of ornithine aminotransferase (OAT). By means of a complementary DNA clone encoding human OAT, the OAT gene sequences were mapped by somatic cell hybrids and in situ hybridization to human chromosome regions 10q26 and Xp11.2. A review of 80 biochemically confirmed cases of gyrate atrophy confirmed the autosomal recessive inheritance of this disease and supported the presence of a functional OAT gene on chromosome 10. Interestingly, the X chromosomes OAT gene sequences (Xp11.2) map to the same region as L1.28 (Xp11.0-p11.3), a marker closely linked to X-linked recessive retinitis pigmentosa.

AB - Gyrate atrophy is a hereditary chorioretinal degeneration associated with a deficiency of ornithine aminotransferase (OAT). By means of a complementary DNA clone encoding human OAT, the OAT gene sequences were mapped by somatic cell hybrids and in situ hybridization to human chromosome regions 10q26 and Xp11.2. A review of 80 biochemically confirmed cases of gyrate atrophy confirmed the autosomal recessive inheritance of this disease and supported the presence of a functional OAT gene on chromosome 10. Interestingly, the X chromosomes OAT gene sequences (Xp11.2) map to the same region as L1.28 (Xp11.0-p11.3), a marker closely linked to X-linked recessive retinitis pigmentosa.

UR - http://www.scopus.com/inward/record.url?scp=0023255426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023255426&partnerID=8YFLogxK

M3 - Article

C2 - 3596985

AN - SCOPUS:0023255426

VL - 28

SP - 1037

EP - 1042

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 7

ER -