Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes

Marie Geneviève Mattei, Michèle Rivière, Andrée Krust, Sigurdur Ingvarsson, Björn Vennström, M. Quamrul Islam, Göran Levan, Philippe Kautner, Arthur Z Zelent, Pierre Chambon, Josiane Szpirer, Claude Szpirer

Research output: Contribution to journalArticle

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Abstract

The human genes encoding the α and β forms of the retinoic acid receptor are known to be located on chromosomes 17 (band q21.1: RARA) and 3 (band p24: RARB). By in situ hybridization, we have now localized the gene for retinoic acid receptor γ, RARG, on chromosome 12, band q13. We also mapped the three retinoic acid receptor genes in the mouse, by in situ hybridization, on chromosomes 11, band D (Rar-a); 14, band A (Rar-b); and 15, band F (Rar-g), respectively, and in the rat, using a panel of somatic cell hybrids that segregate rat chromosomes, on chromosomes 10 (RARA), 15 (RARB), and 7 (RARG), respectively. These assignments reveal a retention of tight linkage between RAR and HOX gene clusters. They also establish or confirm and extend the following homologies: (i) between human chromosome 17, mouse chromosome 11, and rat chromosome 10 (RARA); (ii) between human chromosome 3, mouse chromosome 14, and rat chromosome 15 (RARB); and (iii) between human chromosome 12, mouse chromosome 15, and rat chromosome 7 (RARG).

Original languageEnglish (US)
Pages (from-to)1061-1069
Number of pages9
JournalGenomics
Volume10
Issue number4
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

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Retinoic Acid Receptors
Genome
Human Chromosomes
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 17
Genes
In Situ Hybridization
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 7
Hybrid Cells
Multigene Family
Chromosomes

ASJC Scopus subject areas

  • Genetics

Cite this

Mattei, M. G., Rivière, M., Krust, A., Ingvarsson, S., Vennström, B., Islam, M. Q., ... Szpirer, C. (1991). Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes. Genomics, 10(4), 1061-1069. https://doi.org/10.1016/0888-7543(91)90199-O

Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes. / Mattei, Marie Geneviève; Rivière, Michèle; Krust, Andrée; Ingvarsson, Sigurdur; Vennström, Björn; Islam, M. Quamrul; Levan, Göran; Kautner, Philippe; Zelent, Arthur Z; Chambon, Pierre; Szpirer, Josiane; Szpirer, Claude.

In: Genomics, Vol. 10, No. 4, 01.01.1991, p. 1061-1069.

Research output: Contribution to journalArticle

Mattei, MG, Rivière, M, Krust, A, Ingvarsson, S, Vennström, B, Islam, MQ, Levan, G, Kautner, P, Zelent, AZ, Chambon, P, Szpirer, J & Szpirer, C 1991, 'Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes', Genomics, vol. 10, no. 4, pp. 1061-1069. https://doi.org/10.1016/0888-7543(91)90199-O
Mattei MG, Rivière M, Krust A, Ingvarsson S, Vennström B, Islam MQ et al. Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes. Genomics. 1991 Jan 1;10(4):1061-1069. https://doi.org/10.1016/0888-7543(91)90199-O
Mattei, Marie Geneviève ; Rivière, Michèle ; Krust, Andrée ; Ingvarsson, Sigurdur ; Vennström, Björn ; Islam, M. Quamrul ; Levan, Göran ; Kautner, Philippe ; Zelent, Arthur Z ; Chambon, Pierre ; Szpirer, Josiane ; Szpirer, Claude. / Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes. In: Genomics. 1991 ; Vol. 10, No. 4. pp. 1061-1069.
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