Chromatography and hormonal activities of dog hypothalamus

Andrew V. Schally; Harry S. Lipscomb; John M. Long; Wayne E. Dear; Roger Guillemin

doi:10.1210/endo-70-4-478

Chromatography and hormonal activities of dog hypothalamus

Andrew V. Schally, Harry S. Lipscomb, John M. Long, Wayne E. Dear, Roger Guillemin

Research output: Contribution to journal › Article

30 Scopus citations

Abstract

Extracts of hypothalamus of dogs sacrificed in the laboratory with Nembutal were chromatographed on carboxy- methylcellulose. The following substances were tentatively identified in the effluents based on elution volumes and biological activities: oxytocin, β- and α-MSH, arginine vasopressin, CRF, an α-MSH-like or ACTH- like peptide and ACTH. In the canine hypothalamus, β-MSH and α-MSH are present in much the same ratio in contrast to the porcine tissue.

Original language	English (US)
Pages (from-to)	478-480
Number of pages	3
Journal	Endocrinology
Volume	70
Issue number	4
DOIs	https://doi.org/10.1210/endo-70-4-478
State	Published - Apr 1962
Externally published	Yes

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Keywords

CORTICOTROPIN/chemistry
HYPOTHALAMUS/chemistry
OXYTOCICS/chemistry
PITUITARY GLAND/hormones

ASJC Scopus subject areas

Medicine(all)

Cite this

Schally, A. V., Lipscomb, H. S., Long, J. M., Dear, W. E., & Guillemin, R. (1962). Chromatography and hormonal activities of dog hypothalamus. Endocrinology, 70(4), 478-480. https://doi.org/10.1210/endo-70-4-478

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KW - OXYTOCICS/chemistry

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10.1210/endo-70-4-478