Chromatography and hormonal activities of dog hypothalamus

Andrew V. Schally, Harry S. Lipscomb, John M. Long, Wayne E. Dear, Roger Guillemin

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Extracts of hypothalamus of dogs sacrificed in the laboratory with Nembutal were chromatographed on carboxy- methylcellulose. The following substances were tentatively identified in the effluents based on elution volumes and biological activities: oxytocin, β- and α-MSH, arginine vasopressin, CRF, an α-MSH-like or ACTH- like peptide and ACTH. In the canine hypothalamus, β-MSH and α-MSH are present in much the same ratio in contrast to the porcine tissue.

Original languageEnglish (US)
Pages (from-to)478-480
Number of pages3
Issue number4
StatePublished - Apr 1962
Externally publishedYes


  • CORTICOTROPIN/chemistry
  • HYPOTHALAMUS/chemistry
  • OXYTOCICS/chemistry
  • PITUITARY GLAND/hormones

ASJC Scopus subject areas

  • Medicine(all)


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