TY - JOUR
T1 - Choroidal and Retinal Thickness in Children with Different Refractive Status Measured by Swept-Source Optical Coherence Tomography
AU - Jin, Peiyao
AU - Zou, Haidong
AU - Zhu, Jianfeng
AU - Xu, Xun
AU - Jin, Jiali
AU - Chang, Ta Chen
AU - Lu, Lina
AU - Yuan, Hong
AU - Sun, Sifei
AU - Yan, Bo
AU - He, Jiangnan
AU - Wang, Mingjin
AU - He, Xiangui
N1 - Funding Information:
Funding/Support: Three-year Action Program of Shanghai Municipality for Strengthening the Construction of the Public Health System (2011-2013) (Grant No. GWIII-15); Three-year Action Program of Shanghai Municipality for Strengthening the Construction of the Public Health System (2015-2017) (Grant No. GWIV-13.2); National Natural Science Foundation of China for Young Staff (Grant No. 81402695); Shanghai Natural Science Foundation (Grant No. 15ZR1438400); Shanghai Municipal Health Bureau (Grant No. 20134263); Shanghai Hospital Development Center Municipal Hospital Newly Developing Advanced Technology Joint Research Projects (Grant No. SHDC12012123); Key Discipline of Public Health–Eye health in Shanghai (Grant No. 15GWZK0601); Overseas High-end Research Team–Eye health in Shanghai. Financial Disclosures: The following authors have no financial disclosures: Peiyao Jin, Haidong Zou, Jianfeng Zhu, Xun Xu, Jiali Jin, Ta Chen Chang, Lina Lu, Hong Yuan, Sifei Sun, Bo Yan, Jiangnan He, Mingjin Wang, and Xiangui He. All authors attest that they meet the current ICMJE criteria for authorship.
Publisher Copyright:
© 2016 The Author(s).
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Purpose To investigate the choroidal and retinal thickness in myopic, emmetropic, and hyperopic Chinese children by swept-source longer-wavelength optical coherence tomography. Design Cross-sectional study. Methods Two-hundred and seventy-six schoolchildren aged 7-13 years underwent comprehensive ophthalmic examinations, including cycloplegic refraction, and swept-source optical coherence tomography measurements. The thickness of the choroid, retina, ganglion cell layer, and nerve fiber layer were compared among children of different refractive status. The topographic variation and factors related to the thickness of the choroid and retinal layers were analyzed. Results Compared to emmetropic subjects, those with myopia had a significantly thinner choroid in all regions (P <.01), and hyperopic subjects had a thicker choroid in most regions (P <.05). The myopic retinas were thinner than those of emmetropic or hyperopic subjects in the superior parafoveal and all 4 perifoveal subfields (P <.05), but no other subfields differed significantly among different refractive groups (P >.05). The axial length and refractive diopters were independently related to central foveal choroidal thickness (R2 = 0.17, P <.01), while age and intraocular pressure were independently associated with central fovea retinal (R2 = 0.15, P <.01) and ganglion cell layer thicknesses (R2 = 0.10, P <.01) after adjustment for other systematic and ocular factors. Central foveal choroidal and retinal thickness were unrelated in children of different refractive status (P >.05). Conclusions Choroidal thickness, but not retinal thickness, correlated closely with axial length and refractive diopters in Chinese children. Choroid thinning occurs before retina thinning early in myopic progression.
AB - Purpose To investigate the choroidal and retinal thickness in myopic, emmetropic, and hyperopic Chinese children by swept-source longer-wavelength optical coherence tomography. Design Cross-sectional study. Methods Two-hundred and seventy-six schoolchildren aged 7-13 years underwent comprehensive ophthalmic examinations, including cycloplegic refraction, and swept-source optical coherence tomography measurements. The thickness of the choroid, retina, ganglion cell layer, and nerve fiber layer were compared among children of different refractive status. The topographic variation and factors related to the thickness of the choroid and retinal layers were analyzed. Results Compared to emmetropic subjects, those with myopia had a significantly thinner choroid in all regions (P <.01), and hyperopic subjects had a thicker choroid in most regions (P <.05). The myopic retinas were thinner than those of emmetropic or hyperopic subjects in the superior parafoveal and all 4 perifoveal subfields (P <.05), but no other subfields differed significantly among different refractive groups (P >.05). The axial length and refractive diopters were independently related to central foveal choroidal thickness (R2 = 0.17, P <.01), while age and intraocular pressure were independently associated with central fovea retinal (R2 = 0.15, P <.01) and ganglion cell layer thicknesses (R2 = 0.10, P <.01) after adjustment for other systematic and ocular factors. Central foveal choroidal and retinal thickness were unrelated in children of different refractive status (P >.05). Conclusions Choroidal thickness, but not retinal thickness, correlated closely with axial length and refractive diopters in Chinese children. Choroid thinning occurs before retina thinning early in myopic progression.
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U2 - 10.1016/j.ajo.2016.05.008
DO - 10.1016/j.ajo.2016.05.008
M3 - Article
C2 - 27189931
AN - SCOPUS:84973889748
VL - 168
SP - 164
EP - 176
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
ER -