Choroid plexus selectively accumulates T-lymphocytes in normal controls and after peripheral immune activation

C. K. Petito, B. Adkins

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

We determined T-lymphocyte migration into brain and choroid plexus (CPx) after enterotoxin-induced systemic immune activation. CPx T-lymphocytes/mm 2 in control mice were >3 logs more numerous than brain and increased by as much as 150-fold by post-enterotoxin Day 3 (p<0.01). Flow cytometry of pooled CPx confirmed post-enterotoxin increases. Brain T-lymphocytes increased up to 17-fold after SEB and accumulated in subependymal and periventricular brain. T cell apoptosis was absent. These results show preferential T-lymphocyte migration to CPx over brain and suggest that brain T cells may be derived from the CPx by direct migration or by cerebrospinal fluid dissemination.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalJournal of Neuroimmunology
Volume162
Issue number1-2
DOIs
StatePublished - May 2005

Keywords

  • Blood-brain barrier
  • Central nervous system
  • Choroid plexus
  • Immune activation
  • T-lymphocyte migration

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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