Choroid plexus infection in cerebral toxoplasmosis in AIDS patients

M. F. Falangola, Carol Petito

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

We evaluated the postmortem incidence of choroid plexus infection in cerebral toxoplasmosis in 17 patients with acquired immune deficiency syndrome (AIDS) and cerebral toxoplasmosis and, by immunohistochemistry, identified Toxoplasma gondii tachyzoites in this structure in 53% of all cases. They were present in 78% of the nine cases with the acute necrotizing stages of CNS toxoplasmosis but were less frequent (20%) in patients with only the healed cystic lesions of toxoplasmosis. Large necrotizing abscesses of the choroid plexus were found in three of the patients. In one of these, the choroid plexus was the sole site of CNS infection, which presented as radiographically documented masses in the third and fourth ventricles associated with obstructive hydrocephalus. These results demonstrate that infection of the choroid plexus is common with cerebral toxoplasmosis and suggest that this infection should be included in the differential diagnosis of intra- or periventricular lesions in patients with AIDS. In addition, the high frequency of choroid plexus infection with acute cerebral toxoplasmosis suggests that cerebral toxoplasmosis in the immunosuppressed patient may be due to hematogenous spread to the choroid plexus from reactivation of latent organisms from systemic organs rather than to reactivation of latent organisms within the brain itself. Furthermore, the high frequency of choroid plexitis offers the potential for CSF dissemination of this infection.

Original languageEnglish
Pages (from-to)2035-2040
Number of pages6
JournalNeurology
Volume43
Issue number10
StatePublished - Oct 1 1993

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Cerebral Toxoplasmosis
Choroid Plexus
Acquired Immunodeficiency Syndrome
Infection
Toxoplasmosis
Fourth Ventricle
Third Ventricle
Choroid
Toxoplasma
Hydrocephalus
Abscess
Differential Diagnosis
Immunohistochemistry
Incidence
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Falangola, M. F., & Petito, C. (1993). Choroid plexus infection in cerebral toxoplasmosis in AIDS patients. Neurology, 43(10), 2035-2040.

Choroid plexus infection in cerebral toxoplasmosis in AIDS patients. / Falangola, M. F.; Petito, Carol.

In: Neurology, Vol. 43, No. 10, 01.10.1993, p. 2035-2040.

Research output: Contribution to journalArticle

Falangola, MF & Petito, C 1993, 'Choroid plexus infection in cerebral toxoplasmosis in AIDS patients', Neurology, vol. 43, no. 10, pp. 2035-2040.
Falangola MF, Petito C. Choroid plexus infection in cerebral toxoplasmosis in AIDS patients. Neurology. 1993 Oct 1;43(10):2035-2040.
Falangola, M. F. ; Petito, Carol. / Choroid plexus infection in cerebral toxoplasmosis in AIDS patients. In: Neurology. 1993 ; Vol. 43, No. 10. pp. 2035-2040.
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