Abstract
Three cases of chondromyxoid fibroma arising in the skull base are reported. The tumors arose in females 34, 65, and 66 (median 55) years of age. Two women presented with headaches, and one with nasal obstruction. Radiographic studies revealed that all three lesions were expansile soft tissue masses centered in the clivus, at least 4 cm in greatest diameter. One lesion involved primarily the citrus, the others extended from the clivus into the sphenoid and ethmoid sinuses. Two of the three cases were initially misdiagnosed as chordoma or chondrosarcoma. The initial treatment was curettage of gross disease in all three cases. One patient also received radiation therapy. One patient had local progression of disease, which was treated with surgery and radiation therapy. All patients are clinically free of disease 11 to 26 months following the most recent treatment. Chondromyxoid fibroma can and should be distinguished from chondrosarcoma and chordoma, two tumors which more commonly arise in the skull base and which have the potential to metastasize.
| Original language | English |
|---|---|
| Pages (from-to) | 577-582 |
| Number of pages | 6 |
| Journal | American Journal of Surgical Pathology |
| Volume | 21 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 1997 |
| Externally published | Yes |
Fingerprint
Keywords
- Chondromyxoid fibroma
- Chondrosarcoma
- Chordoma
- Clivus
- Skull base
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
Cite this
Chondromyxoid fibroma of the skull base : A tumor which may be confused with chordoma and chondrosarcoma: A report of three cases and review of the literature. / Keel, Suzanne B.; Bhan, Atul K.; Liebsch, Norbert J.; Rosenberg, Andrew.
In: American Journal of Surgical Pathology, Vol. 21, No. 5, 01.05.1997, p. 577-582.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chondromyxoid fibroma of the skull base
T2 - A tumor which may be confused with chordoma and chondrosarcoma: A report of three cases and review of the literature
AU - Keel, Suzanne B.
AU - Bhan, Atul K.
AU - Liebsch, Norbert J.
AU - Rosenberg, Andrew
PY - 1997/5/1
Y1 - 1997/5/1
N2 - Three cases of chondromyxoid fibroma arising in the skull base are reported. The tumors arose in females 34, 65, and 66 (median 55) years of age. Two women presented with headaches, and one with nasal obstruction. Radiographic studies revealed that all three lesions were expansile soft tissue masses centered in the clivus, at least 4 cm in greatest diameter. One lesion involved primarily the citrus, the others extended from the clivus into the sphenoid and ethmoid sinuses. Two of the three cases were initially misdiagnosed as chordoma or chondrosarcoma. The initial treatment was curettage of gross disease in all three cases. One patient also received radiation therapy. One patient had local progression of disease, which was treated with surgery and radiation therapy. All patients are clinically free of disease 11 to 26 months following the most recent treatment. Chondromyxoid fibroma can and should be distinguished from chondrosarcoma and chordoma, two tumors which more commonly arise in the skull base and which have the potential to metastasize.
AB - Three cases of chondromyxoid fibroma arising in the skull base are reported. The tumors arose in females 34, 65, and 66 (median 55) years of age. Two women presented with headaches, and one with nasal obstruction. Radiographic studies revealed that all three lesions were expansile soft tissue masses centered in the clivus, at least 4 cm in greatest diameter. One lesion involved primarily the citrus, the others extended from the clivus into the sphenoid and ethmoid sinuses. Two of the three cases were initially misdiagnosed as chordoma or chondrosarcoma. The initial treatment was curettage of gross disease in all three cases. One patient also received radiation therapy. One patient had local progression of disease, which was treated with surgery and radiation therapy. All patients are clinically free of disease 11 to 26 months following the most recent treatment. Chondromyxoid fibroma can and should be distinguished from chondrosarcoma and chordoma, two tumors which more commonly arise in the skull base and which have the potential to metastasize.
KW - Chondromyxoid fibroma
KW - Chondrosarcoma
KW - Chordoma
KW - Clivus
KW - Skull base
UR - http://www.scopus.com/inward/record.url?scp=0030971603&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030971603&partnerID=8YFLogxK
U2 - 10.1097/00000478-199705000-00011
DO - 10.1097/00000478-199705000-00011
M3 - Article
C2 - 9158683
AN - SCOPUS:0030971603
VL - 21
SP - 577
EP - 582
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
SN - 0147-5185
IS - 5
ER -