Chondromyxoid fibroma of the skull base

A tumor which may be confused with chordoma and chondrosarcoma: A report of three cases and review of the literature

Suzanne B. Keel, Atul K. Bhan, Norbert J. Liebsch, Andrew Rosenberg

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Three cases of chondromyxoid fibroma arising in the skull base are reported. The tumors arose in females 34, 65, and 66 (median 55) years of age. Two women presented with headaches, and one with nasal obstruction. Radiographic studies revealed that all three lesions were expansile soft tissue masses centered in the clivus, at least 4 cm in greatest diameter. One lesion involved primarily the citrus, the others extended from the clivus into the sphenoid and ethmoid sinuses. Two of the three cases were initially misdiagnosed as chordoma or chondrosarcoma. The initial treatment was curettage of gross disease in all three cases. One patient also received radiation therapy. One patient had local progression of disease, which was treated with surgery and radiation therapy. All patients are clinically free of disease 11 to 26 months following the most recent treatment. Chondromyxoid fibroma can and should be distinguished from chondrosarcoma and chordoma, two tumors which more commonly arise in the skull base and which have the potential to metastasize.

Original languageEnglish
Pages (from-to)577-582
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume21
Issue number5
DOIs
StatePublished - May 1 1997
Externally publishedYes

Fingerprint

Chordoma
Chondrosarcoma
Fibroma
Skull Base
Posterior Cranial Fossa
Radiotherapy
Ethmoid Sinus
Sphenoid Sinus
Neoplasms
Nasal Obstruction
Curettage
Citrus
Diagnostic Errors
Headache
Disease Progression
Therapeutics

Keywords

  • Chondromyxoid fibroma
  • Chondrosarcoma
  • Chordoma
  • Clivus
  • Skull base

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Chondromyxoid fibroma of the skull base : A tumor which may be confused with chordoma and chondrosarcoma: A report of three cases and review of the literature. / Keel, Suzanne B.; Bhan, Atul K.; Liebsch, Norbert J.; Rosenberg, Andrew.

In: American Journal of Surgical Pathology, Vol. 21, No. 5, 01.05.1997, p. 577-582.

Research output: Contribution to journalArticle

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