Chondroblastoma-like chondroma of soft tissue: An underrecognized variant and its differential diagnosis

Justin M. Cates, Andrew E. Rosenberg, John X. O'Connell, G. Petur Nielsen

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Soft-tissue chondromas are usually composed entirely of mature hyaline cartilage. Infrequently, however, they may exhibit morphologic features that result in diagnostic difficulty. The authors report a series of right hypercellular soft-tissue chondromas composed of enlarged chondrocytes within a variable amount of chondroid matrix that often demonstrated delicate calcifications and contained numerous osteoclast-like multinucleated giant cells. This histologic appearance closely resembles that of chondroblastoma of bone. However, its extraosseous location, dense cellularity, and poorly formed cartilage can cause confusion with more aggressive chondroid neoplasms of soft tissue. The clinicopathologic features of these chondroblastoma-like chondromas are discussed, emphasizing the characteristics that facilitate their accurate identification.

Original languageEnglish (US)
Pages (from-to)661-666
Number of pages6
JournalAmerican Journal of Surgical Pathology
Issue number5
StatePublished - May 21 2001
Externally publishedYes


  • Chondroblastoma
  • Chondroblastoma-like chondroma
  • Soft-tissue chondroma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine


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