TY - JOUR
T1 - Cholinergic processes in blood samples from patients with major psychiatric disorders
AU - Jope, Richard S.
AU - Walter-Ryan, William G.
AU - Alarcon, Renato D.
AU - Lally, Kathleen M.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1985/12
Y1 - 1985/12
N2 - Cholinergic processes were measured in plasma and red blood cells (RBC) obtained from patients with mania, depression, and schizophrenia. RBC choline levels were elevated in manic patients, and lithium treatment led to a further increase. RBC choline transport was below normal in manic patients, and lithium treatment further reduced choline transport in addition to reducing the apparent affinity for choline. RBC acetylcholinesterase was low in depressed and schizophrenic patients, but not in manic patients, whereas plasma acetylcholinesterase was reduced only in depressed patients. Plasma nonspecific cholinesterase was below normal in all groups of patients. These results indicate unique patterns of differences from controls in the cholinergic system in blood samples from patients with different psychiatric illnesses.
AB - Cholinergic processes were measured in plasma and red blood cells (RBC) obtained from patients with mania, depression, and schizophrenia. RBC choline levels were elevated in manic patients, and lithium treatment led to a further increase. RBC choline transport was below normal in manic patients, and lithium treatment further reduced choline transport in addition to reducing the apparent affinity for choline. RBC acetylcholinesterase was low in depressed and schizophrenic patients, but not in manic patients, whereas plasma acetylcholinesterase was reduced only in depressed patients. Plasma nonspecific cholinesterase was below normal in all groups of patients. These results indicate unique patterns of differences from controls in the cholinergic system in blood samples from patients with different psychiatric illnesses.
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U2 - 10.1016/0006-3223(85)90110-6
DO - 10.1016/0006-3223(85)90110-6
M3 - Article
C2 - 4063416
AN - SCOPUS:0022250135
VL - 20
SP - 1258
EP - 1266
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 12
ER -