Cholinergic function in lumbar aluminum myelopathy

K. S. Kosik, Walter G Bradley, P. F. Good, C. G. Rasool, D. J. Selkoe

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

To determine whether perikaryal neurofilamentous accumulation in cholinergic neurons is associated with a deficit in cholinergic function, the authors developed a new model of aluminum-induced neurofibrillary degeneration, referred to as focal lumbar aluminum myelopathy. The model is produced by direct intramedullary microinjection of AlCl3, which results in a characteristic neurological syndrome. Four weeks after injections, affected rabbits show extensive neurofilamentous lesions of both large and small neurons in the lumbar spinal cord, including a majority of anterior horn cells. These animals are capable of long-term survival. Posterior tibial nerve morphometry in these rabbits revealed no significant loss of myelinated fibers. Choline acetyltransferase (ChAT) activity in the sciatic nerve was decreased 39%, from 45.70 ± 2.36 nmol ACh/hour/3-mm segment in acid-injected controls to 17.72 ± 1.94 in aluminum-intoxicated rabbits. The rate of accumulation of ChAT activity proximal to a sciatic nerve ligature was significantly greater in the aluminum-treated rabbits, although the total amount of ChAT activity accumulating in a 24-hour period did not differ from controls. It is concluded that aluminum-induced accumulation of neurofilaments in cholinergic perikarya is associated with a sharp decrease of ChAT activity in the axons of those cells and possibly with a compensatory increase in the rate of delivery of the enzyme.

Original languageEnglish
Pages (from-to)365-375
Number of pages11
JournalJournal of Neuropathology and Experimental Neurology
Volume42
Issue number4
StatePublished - Sep 23 1983
Externally publishedYes

Fingerprint

Spinal Cord Diseases
Aluminum
Choline O-Acetyltransferase
Cholinergic Agents
Rabbits
Sciatic Nerve
Spinal Cord
Anterior Horn Cells
Tibial Nerve
Cholinergic Neurons
Intermediate Filaments
Microinjections
Ligation
Axons
Neurons
Injections
Acids
Enzymes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Kosik, K. S., Bradley, W. G., Good, P. F., Rasool, C. G., & Selkoe, D. J. (1983). Cholinergic function in lumbar aluminum myelopathy. Journal of Neuropathology and Experimental Neurology, 42(4), 365-375.

Cholinergic function in lumbar aluminum myelopathy. / Kosik, K. S.; Bradley, Walter G; Good, P. F.; Rasool, C. G.; Selkoe, D. J.

In: Journal of Neuropathology and Experimental Neurology, Vol. 42, No. 4, 23.09.1983, p. 365-375.

Research output: Contribution to journalArticle

Kosik, KS, Bradley, WG, Good, PF, Rasool, CG & Selkoe, DJ 1983, 'Cholinergic function in lumbar aluminum myelopathy', Journal of Neuropathology and Experimental Neurology, vol. 42, no. 4, pp. 365-375.
Kosik, K. S. ; Bradley, Walter G ; Good, P. F. ; Rasool, C. G. ; Selkoe, D. J. / Cholinergic function in lumbar aluminum myelopathy. In: Journal of Neuropathology and Experimental Neurology. 1983 ; Vol. 42, No. 4. pp. 365-375.
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