Cholinergic agonists selectively induce proliferative responses in the mature subpopulation of murine thymocytes

A. Rossi, M. A. Tria, S. Baschieri, G. Doria, D. Frasca

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The incubation of murine thymocytes for 24 hr in the presence of cholinergic agonists induces selective proliferation of PNA- cells as measured by thymidine incorporation. The response of PNA- cells is mediated by the activation of nicotinic receptors. This conclusion is suggested by the inability of the muscarinic agonist, oxotremorine, to induce cell proliferation and by the inhibition exerted by the nicotinic antagonist, d-tubo-curarine. The presence of cholinergic axons in the murine thymus adds biological interest to the selective expression of functional cholinergic receptors on mature thymocytes.

Original languageEnglish (US)
Pages (from-to)369-373
Number of pages5
JournalJournal of Neuroscience Research
Volume24
Issue number3
DOIs
StatePublished - Nov 1989
Externally publishedYes

Keywords

  • Cholinergic system
  • Lymphoproliferation
  • Neuroimmunomodulation

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Cholinergic agonists selectively induce proliferative responses in the mature subpopulation of murine thymocytes'. Together they form a unique fingerprint.

  • Cite this