To the Editor: Lithium is currently the treatment of choice for mania, having been used experimentally with some success in a variety of other disorders. Treatment is usually monitored by measurement of the concentration of the drug in plasma, 0.8 to 1.2 meq per liter being the generally accepted optimum concentration. Mendels and Frazer1 suggested that it may be more informative to measure the ratio of the concentration in erythrocytes to that in plasma, and reported that the drug is accumulated in erythrocytes of depressed patients who respond to lithium therapy. This finding awaits confirmation. We should like to report. No extract is available for articles shorter than 400 words.
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