Cholestatic Liver Diseases After Liver Transplant

Nathalie A. Pena Polanco, Cynthia Levy, Eric Martin

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common cholestatic liver diseases (CLD) in adults. Liver transplant (LT) is desirable for those who progress to end-stage liver disease. CLD have become an uncommon indication for LT. PSC and PBC accounted for 7.1% of all adult LT in 2015. CLD have the best post-LT outcomes compared with other indications for LT. Disease recurrence of PSC and PBC after LT is reported in up to 37% and 43% of LT recipients, respectively. Although recurrent PBC does not affect post-LT outcomes, recurrent PSC is associated with worse post-LT survival.

Original languageEnglish (US)
Pages (from-to)403-420
Number of pages18
JournalClinics in Liver Disease
Volume21
Issue number2
DOIs
StatePublished - May 1 2017

Keywords

  • Cholestatic liver disease
  • Liver transplant
  • Outcomes
  • Primary biliary cholangitis
  • Primary sclerosing cholangitis
  • Recurrence

ASJC Scopus subject areas

  • Hepatology

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