Cholecystokinin inhibits tail pinch-induced eating in rats

Charles B. Nemeroff, Albert J. Osbahr, Garth Bissette, Gloria Jahnke, Morris A. Lipton, Arthur J. Prange

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

Peripheral administration of the COOH-terminal octapeptide of cholecystokinin in doses from 1 to 100 micrograms per kilogram of body weight (0.25 to 25.0 micrograms per rat) significantly antagonized tail pinch-induced eating in rats, an animal model for stress-induced human hyperphagia. Centrally administered cholecystokinin was effective only in high doses (3 micrograms into the cerebral ventricle). The finding that the minimal effective dose of cholecystokinin in suppressing stress-induced appetitive behavior is smaller after peripheral than central administration suggests that the peptide is acting on peripheral, as opposed to central nervous system, substrates.

Original languageEnglish (US)
Pages (from-to)793-794
Number of pages2
JournalScience
Volume200
Issue number4343
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Cholecystokinin inhibits tail pinch-induced eating in rats'. Together they form a unique fingerprint.

  • Cite this

    Nemeroff, C. B., Osbahr, A. J., Bissette, G., Jahnke, G., Lipton, M. A., & Prange, A. J. (1978). Cholecystokinin inhibits tail pinch-induced eating in rats. Science, 200(4343), 793-794. https://doi.org/10.1126/science.565535