Cholecystokinin inhibits tail pinch-induced eating in rats

Charles B. Nemeroff, Albert J. Osbahr, Garth Bissette, Gloria Jahnke, Morris A. Lipton, Arthur J. Prange

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Peripheral administration of the COOH-terminal octapeptide of cholecystokinin in doses from 1 to 100 micrograms per kilogram of body weight (0.25 to 25.0 micrograms per rat) significantly antagonized tail pinch-induced eating in rats, an animal model for stress-induced human hyperphagia. Centrally administered cholecystokinin was effective only in high doses (3 micrograms into the cerebral ventricle). The finding that the minimal effective dose of cholecystokinin in suppressing stress-induced appetitive behavior is smaller after peripheral than central administration suggests that the peptide is acting on peripheral, as opposed to central nervous system, substrates.

Original languageEnglish (US)
Pages (from-to)793-794
Number of pages2
Issue number4343
StatePublished - Jan 1 1978
Externally publishedYes

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    Nemeroff, C. B., Osbahr, A. J., Bissette, G., Jahnke, G., Lipton, M. A., & Prange, A. J. (1978). Cholecystokinin inhibits tail pinch-induced eating in rats. Science, 200(4343), 793-794.