Chlorhexidine-based antiseptic solutions effectively reduce catheter-related bacteremia

Ali Mirza Onder, Jayanthi Chandar, Anthony Billings, Rosa Diaz, Denise Francoeur, Carolyn Abitbol, Gaston Zilleruelo

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The aim of this retrospective study was to investigate if the application of chlorhexidine-based solutions (ChloraPrep®) to the exit site and the hub of long-term hemodialysis catheters could prevent catheter-related bacteremia (CRB) and prolong catheter survival when compared with povidone-iodine solutions. There were 20,784 catheter days observed. Povidone-iodine solutions (Betadine®) were used in the first half of the study and ChloraPrep® was used in the second half for all the patients. Both groups received chlorhexidine-impregnated dressings at the exit sites. The use of Chloraprep® significantly decreased the incidence of CRB (1.0 vs 2.2/1,000 catheter days, respectively, P = 0.0415), and hospitalization due to CRB (1.8 days vs 4.1 days/1,000 catheter days, respectively, P = 0.0416). The incidence of exit site infection was similar for the two groups. Both the period of overall catheter survival (207.6 days vs 161.1 days, P = 0.0535) and that of infection-free catheter survival (122.0 days vs 106.9 days, P = 0.1100) tended to be longer for the catheters cleansed with ChloraPrep®, with no statistical significance. In conclusion, chlorhexidine-based solutions are more effective for the prevention of CRB than povidone-iodine solutions. This positive impact cannot be explained by decreased number of exit site infections. This study supports the notion that the catheter hub is the entry site for CRB.

Original languageEnglish (US)
Pages (from-to)1741-1747
Number of pages7
JournalPediatric Nephrology
Volume24
Issue number9
DOIs
StatePublished - Apr 8 2009

Keywords

  • Catheter survival
  • Catheter-related bacteremia
  • Children
  • Chlorhexidine
  • Povidone-iodine

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

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