Chlamydia pneumoniae impairs the innate immune response in infected epithelial cells by targeting TRAF3

Katerina Wolf, Kenneth A. Fields

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Type I IFNs are induced during microbial infections and have well-characterized antiviral activities. TRAF3 is a signaling molecule crucial for type I IFN production and, therefore, represents a potential target for disarming immune responses. Chlamydia pneumoniae is a human pathogen that primarily infects respiratory epithelial cells; the onset of symptoms takes several weeks, and the course of infection is protracted. C. pneumoniae has also been associated with a variety of chronic inflammatory conditions. Thus, typical C. pneumoniae infections of humans are consistent with an impairment in inflammatory responses to the microorganism. We demonstrate that infection of epithelial cells with C. pneumoniae does not lead to IFN-β production. Instead, infected cells are prevented from activating IFN regulatory factor 3. This effect is mediated by C. pneumoniae-dependent degradation of TRAF3, which is independent of a functional proteasome. Hence, it is likely that C. pneumoniae expresses a unique protease targeting TRAF3-dependent immune effector mechanisms.

Original languageEnglish
Pages (from-to)1695-1701
Number of pages7
JournalJournal of Immunology
Volume190
Issue number4
DOIs
StatePublished - Feb 15 2013

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TNF Receptor-Associated Factor 3
Chlamydophila pneumoniae
Innate Immunity
Epithelial Cells
Infection
Interferon Regulatory Factor-3
Chlamydia Infections
Proteasome Endopeptidase Complex
Antiviral Agents
Peptide Hydrolases

ASJC Scopus subject areas

  • Immunology

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Chlamydia pneumoniae impairs the innate immune response in infected epithelial cells by targeting TRAF3. / Wolf, Katerina; Fields, Kenneth A.

In: Journal of Immunology, Vol. 190, No. 4, 15.02.2013, p. 1695-1701.

Research output: Contribution to journalArticle

Wolf, Katerina ; Fields, Kenneth A. / Chlamydia pneumoniae impairs the innate immune response in infected epithelial cells by targeting TRAF3. In: Journal of Immunology. 2013 ; Vol. 190, No. 4. pp. 1695-1701.
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