Chimpanzee MHC class I A locus alleles are related to only one of the six families of human A locus alleles

S. N. McAdam, J. E. Boyson, X. Liu, T. L. Garber, A. L. Hughes, R. E. Bontrop, D. I. Watkins

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Abstract

There are nearly 50 alleles at the highly polymorphic HLA-A class I locus that fall into six distinct families. To determine the allelic repertoire and the mechanism of generation of diversity of the A locus in primates we have analyzed A locus alleles from 28 apparently unrelated chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). We have, therefore, compared the sequences of 19 HLA-A homologues from chimpanzees and bonobos to 42 HLA-A sequences. HLA-A homologues were well preserved in chimpanzees and bonobos with very few new substitutions present in the A locus alleles of both species of chimpanzee. Surprisingly, all chimpanzees and bonobos expressed A locus alleles related to only one of the six families of human HLA-A alleles. This suggests that the common ancestor of these two species either passed through a genetic bottleneck or that selection has favored the maintenance of the HLA-A1, -A3, -A11 family in chimpanzees.

Original languageEnglish (US)
Pages (from-to)6421-6429
Number of pages9
JournalJournal of Immunology
Volume154
Issue number12
StatePublished - Jan 1 1995
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

McAdam, S. N., Boyson, J. E., Liu, X., Garber, T. L., Hughes, A. L., Bontrop, R. E., & Watkins, D. I. (1995). Chimpanzee MHC class I A locus alleles are related to only one of the six families of human A locus alleles. Journal of Immunology, 154(12), 6421-6429.