Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation

Thomas E. Starzl, Anthony J. Demetris, Massimo Trucco, Adriana Zeevi, Hector Ramos, Paul Terasaki, William A. Rudert, Mirjana Kocova, Camillo Ricordi, Suzanne Ildstad, Noriko Murase

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284 Scopus citations

Abstract

Chimerism was demonstrated with immunocytochemical and/or polymerase chain reaction techniques in kidney allografts and in the native skin, lymph nodes, or blood of 5 of 5 patients who received continuously functioning renal transplants from 1 or 2 haplotype HLA mismatched consanguineous donors (4 parents, 1 aunt) 27-29 years ago. In the 4 cases where the kidney donor still was alive to provide stimulator lymphocytes for testing, these provoked no (n=2) or modest (n=2) MLR in contrast to vigorous MLR to third party lymphocytes. In all 4 cases, the donor cells failed to generate in vitro cytotoxic effector cells (cell-mediated lymphocytotoxicity). These findings are in accord with the hypothesis that cell migration, repopulation, and chimerism are seminal events that define graft acceptance and ultimately can lead to acquired donor-specific nonresponsiveness (tolerance).

Original languageEnglish (US)
Pages (from-to)1272-1277
Number of pages6
JournalTransplantation
Volume55
Issue number6
DOIs
StatePublished - Jun 1993

ASJC Scopus subject areas

  • Transplantation

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    Starzl, T. E., Demetris, A. J., Trucco, M., Zeevi, A., Ramos, H., Terasaki, P., Rudert, W. A., Kocova, M., Ricordi, C., Ildstad, S., & Murase, N. (1993). Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation. Transplantation, 55(6), 1272-1277. https://doi.org/10.1097/00007890-199306000-00012