Childhood malignant melanoma: Incidence and etiology

Judith L. Bader, Frederick P. Li, P. Michael Olmstead, Nancy A. Strickman, Daniel M. Green

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Etiology of malignant melanoma in persons younger than 20 years of age was examined using data from two sources: 1) medical records of 78 patients with this diagnosis at six hospitals, and 2) information on 101 individuals included in 10 U.S. population-based SEER cancer registry areas between 1973-1976. Annual melanoma incidence rate was 3.4 per million in boys, 3.9 per million in girls, and 10-fold greater in white children than in black children. Melanoma was seven times more frequent in the second decade of life than the first. Skin was the primary site of melanoma in approximately 90% of the children in the two study series. The predominant cutaneous sites were head, neck, and trunk among boys, and arms and legs among girls. These variations by age, race, and sex suggest the etiologic role of cumulative skin exposure to sunlight, particularly in two patients with xeroderma pigmentosum. In 14 patients in the hospital series, melanoma was report to develop within pigmented nevi that were present at birth.

Original languageEnglish (US)
Pages (from-to)341-345
Number of pages5
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume7
Issue number4
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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    Bader, J. L., Li, F. P., Olmstead, P. M., Strickman, N. A., & Green, D. M. (1985). Childhood malignant melanoma: Incidence and etiology. American Journal of Pediatric Hematology/Oncology, 7(4), 341-345.