Childhood autism: A circuit syndrome?

Deborah A. Lee, Roberto Lopez Alberola, Meena Bhattacharjee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

BACKGROUND - Autism is a disorder that can lead to life-long disability. Currently, the etiology of autism is unknown, and although there are treatments for some of the behavioral abnormalities, there is no cure. REVIEW SUMMARY - While this article will review the clinical, anatomic, and pathologic features seen in autism, the primary focus will be to present a new and provocative unifying theory regarding the underlying mechanisms causing this disorder. Current research advances, some controversial, will be discussed, and a novel definition of autism as a "circuit syndrome" will be presented. The work elaborated here will tie many of the disparate findings together, based on the idea that autism arises from abnormalities of the cerebellolimbic circuitry. Some of the more alternative theories of autism, such as mercury toxicity, linkage to the measles, mumps, and rubella vaccine, and the use of secretin will be discussed. Finally, pharmacologic treatment options will be reviewed. CONCLUSIONS - Autism is not single disorder but represents dysfunction of the cerebellolimbic circuitry that can arise from many different etiologies.

Original languageEnglish
Pages (from-to)99-109
Number of pages11
JournalNeurologist
Volume9
Issue number2
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

Fingerprint

Autistic Disorder
Measles-Mumps-Rubella Vaccine
Secretin
Mercury
Therapeutics
Research

Keywords

  • Autism
  • Cerebellum
  • Limbic system
  • Serotonin

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Childhood autism : A circuit syndrome? / Lee, Deborah A.; Lopez Alberola, Roberto; Bhattacharjee, Meena.

In: Neurologist, Vol. 9, No. 2, 01.03.2003, p. 99-109.

Research output: Contribution to journalArticle

Lee, Deborah A. ; Lopez Alberola, Roberto ; Bhattacharjee, Meena. / Childhood autism : A circuit syndrome?. In: Neurologist. 2003 ; Vol. 9, No. 2. pp. 99-109.
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