Abstract
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects. We reexamined both interactions for lifetime MDD in a college sample. Lifetime MDD was diagnosed by Structured Clinical Interview for DSM-IV in 133 undergraduates; genotypes for 5-HTTLPR and BDNF were assayed from blood, and self-reports were collected concerning childhood adversity (Risk). 5-HTTLPR interacted with Risk such that Risk predicted less likelihood of MDD among ll carriers and tended to predict greater likelihood of MDD among s carriers. BDNF interacted with Risk such that Risk predicted greater likelihood of MDD among met carriers and did not influence val/val carriers. These two interactions were additive: both were significant in a combined model.
| Original language | English |
|---|---|
| Pages (from-to) | 89-93 |
| Number of pages | 5 |
| Journal | Journal of Affective Disorders |
| Volume | 132 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jul 1 2011 |
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Keywords
- 5-HTTLPR
- BDNF
- Depression
- Gene × environment
- Genotype
- Serotonin transporter
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis. / Carver, Charles S; Johnson, Sheri L.; Joormann, Jutta; Lemoult, Joelle; Cuccaro, Michael.
In: Journal of Affective Disorders, Vol. 132, No. 1-2, 01.07.2011, p. 89-93.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis
AU - Carver, Charles S
AU - Johnson, Sheri L.
AU - Joormann, Jutta
AU - Lemoult, Joelle
AU - Cuccaro, Michael
PY - 2011/7/1
Y1 - 2011/7/1
N2 - The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects. We reexamined both interactions for lifetime MDD in a college sample. Lifetime MDD was diagnosed by Structured Clinical Interview for DSM-IV in 133 undergraduates; genotypes for 5-HTTLPR and BDNF were assayed from blood, and self-reports were collected concerning childhood adversity (Risk). 5-HTTLPR interacted with Risk such that Risk predicted less likelihood of MDD among ll carriers and tended to predict greater likelihood of MDD among s carriers. BDNF interacted with Risk such that Risk predicted greater likelihood of MDD among met carriers and did not influence val/val carriers. These two interactions were additive: both were significant in a combined model.
AB - The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects. We reexamined both interactions for lifetime MDD in a college sample. Lifetime MDD was diagnosed by Structured Clinical Interview for DSM-IV in 133 undergraduates; genotypes for 5-HTTLPR and BDNF were assayed from blood, and self-reports were collected concerning childhood adversity (Risk). 5-HTTLPR interacted with Risk such that Risk predicted less likelihood of MDD among ll carriers and tended to predict greater likelihood of MDD among s carriers. BDNF interacted with Risk such that Risk predicted greater likelihood of MDD among met carriers and did not influence val/val carriers. These two interactions were additive: both were significant in a combined model.
KW - 5-HTTLPR
KW - BDNF
KW - Depression
KW - Gene × environment
KW - Genotype
KW - Serotonin transporter
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U2 - 10.1016/j.jad.2011.02.001
DO - 10.1016/j.jad.2011.02.001
M3 - Article
VL - 132
SP - 89
EP - 93
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1-2
ER -