Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis

Charles S Carver, Sheri L. Johnson, Jutta Joormann, Joelle Lemoult, Michael Cuccaro

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects. We reexamined both interactions for lifetime MDD in a college sample. Lifetime MDD was diagnosed by Structured Clinical Interview for DSM-IV in 133 undergraduates; genotypes for 5-HTTLPR and BDNF were assayed from blood, and self-reports were collected concerning childhood adversity (Risk). 5-HTTLPR interacted with Risk such that Risk predicted less likelihood of MDD among ll carriers and tended to predict greater likelihood of MDD among s carriers. BDNF interacted with Risk such that Risk predicted greater likelihood of MDD among met carriers and did not influence val/val carriers. These two interactions were additive: both were significant in a combined model.

Original languageEnglish
Pages (from-to)89-93
Number of pages5
JournalJournal of Affective Disorders
Volume132
Issue number1-2
DOIs
StatePublished - Jul 1 2011

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Brain-Derived Neurotrophic Factor
Serotonin Plasma Membrane Transport Proteins
Diagnostic and Statistical Manual of Mental Disorders
Self Report
Genotype
Interviews

Keywords

  • 5-HTTLPR
  • BDNF
  • Depression
  • Gene × environment
  • Genotype
  • Serotonin transporter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis. / Carver, Charles S; Johnson, Sheri L.; Joormann, Jutta; Lemoult, Joelle; Cuccaro, Michael.

In: Journal of Affective Disorders, Vol. 132, No. 1-2, 01.07.2011, p. 89-93.

Research output: Contribution to journalArticle

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