Abstract
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects. We reexamined both interactions for lifetime MDD in a college sample. Lifetime MDD was diagnosed by Structured Clinical Interview for DSM-IV in 133 undergraduates; genotypes for 5-HTTLPR and BDNF were assayed from blood, and self-reports were collected concerning childhood adversity (Risk). 5-HTTLPR interacted with Risk such that Risk predicted less likelihood of MDD among ll carriers and tended to predict greater likelihood of MDD among s carriers. BDNF interacted with Risk such that Risk predicted greater likelihood of MDD among met carriers and did not influence val/val carriers. These two interactions were additive: both were significant in a combined model.
Original language | English (US) |
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Pages (from-to) | 89-93 |
Number of pages | 5 |
Journal | Journal of affective disorders |
Volume | 132 |
Issue number | 1-2 |
DOIs | |
State | Published - Jul 2011 |
Keywords
- 5-HTTLPR
- BDNF
- Depression
- Gene × environment
- Genotype
- Serotonin transporter
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology