Chemotherapy-induced hepatotoxicity

Ameet V. Thatishetty, Nicholas Agresti, Christopher B. O'Brien

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Most hepatotoxicity secondary to chemotherapy is idiosyncratic and, therefore, neither dose dependent nor predictable. Some chemotherapy is cleared by the liver and requires dose adjustment in the face of significant liver dysfunction. In addition, preexisting abnormal liver function has been shown to increase the risk of hepatotoxicity. In addition to typical hepatocellular injury, other presentations, including cholestasis and hepatic sinusoidal obstruction syndrome, also commonly occur. The outcomes can range from asymptomatic liver function test abnormalities, which resolve spontaneously, to cirrhosis, which occurs despite discontinuation of the chemotherapeutic agent.

Original languageEnglish (US)
Pages (from-to)671-686
Number of pages16
JournalClinics in liver disease
Volume17
Issue number4
DOIs
StatePublished - Nov 1 2013

Keywords

  • Cancer
  • Chemotherapy
  • Drugs
  • Hepatotoxicity
  • Liver

ASJC Scopus subject areas

  • Hepatology

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