TY - JOUR
T1 - Chemotherapy-induced alopecia in mice
T2 - Induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone
AU - Paus, Ralf
AU - Handjiski, Bori
AU - Eichmüller, Stefan
AU - Czarnetzki, Beate M.
PY - 1994/4
Y1 - 1994/4
N2 - We introduce cyclophosphamide-induced alopecia (CYP-IA) in C 57 BL-6 mice as a clinically relevant model for studying the biology of chemotherapy- induced alopecia and for developing anti-alopecia drugs. One injection of CYP to mice with all back skin follicles in anagen VI induces severe alopecia that strikingly reproduces the follicle response, recovery, and histopathology seen in human CYP-IA. CYP dose-dependently induces abnormal follicular melanogenesis and dystrophic anagen or, in more severely damaged follicles, dystrophic catagen. Both dystrophy forms are followed by an extremely shortened telogen phase, but differ in the associated hair loss and in recovery patterns, which determines hair regrowth. This follicular response to CYP can be manipulated pharmacologically: systemic cyclosporine A shifts it toward a mild form of dystrophic anagen, thus retarding CYP-IA and prolonging 'primary recovery'. Topical dexamethasone, in contrast, forces follicles into dystrophic catagen, which augments CYP-IA, but accelerates the regrowth of normally pigmented hair ('secondary recovery').
AB - We introduce cyclophosphamide-induced alopecia (CYP-IA) in C 57 BL-6 mice as a clinically relevant model for studying the biology of chemotherapy- induced alopecia and for developing anti-alopecia drugs. One injection of CYP to mice with all back skin follicles in anagen VI induces severe alopecia that strikingly reproduces the follicle response, recovery, and histopathology seen in human CYP-IA. CYP dose-dependently induces abnormal follicular melanogenesis and dystrophic anagen or, in more severely damaged follicles, dystrophic catagen. Both dystrophy forms are followed by an extremely shortened telogen phase, but differ in the associated hair loss and in recovery patterns, which determines hair regrowth. This follicular response to CYP can be manipulated pharmacologically: systemic cyclosporine A shifts it toward a mild form of dystrophic anagen, thus retarding CYP-IA and prolonging 'primary recovery'. Topical dexamethasone, in contrast, forces follicles into dystrophic catagen, which augments CYP-IA, but accelerates the regrowth of normally pigmented hair ('secondary recovery').
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M3 - Article
C2 - 8160773
AN - SCOPUS:0028356009
VL - 144
SP - 719
EP - 734
JO - American Journal of Pathology
JF - American Journal of Pathology
SN - 0002-9440
IS - 4
ER -