Chemotherapy for metastatic Merkel cell carcinoma: Review of the M.D. Anderson Hospital's experience

Lynn G Feun, Niramol Savaraj, S. S. Legha, E. G. Silva, R. S. Benjamin, M. A. Burgess

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Thirteen patients with regional or distant metastases from Merkel cell carcinoma were treated with combination chemotherapy. Three patients had a complete response to therapy. In two patients with nodal disease the duration of response was 10+ and 4+ years. In addition, three patients had a partial response, and six patients had minor responses. Chemotherapy using a combination of drugs that are active against small cell carcinoma of the lung is recommended in the treatment of unresectable disease in patients with Merkel cell carcinoma; it may produce prolonged responses. While tumor regressions as a result of chemotherapy were often dramatic, once the disease progressed, the course of the disease often moved rapidly downhill and proved to be fatal.

Original languageEnglish
Pages (from-to)683-685
Number of pages3
JournalCancer
Volume62
Issue number4
StatePublished - Jan 1 1988
Externally publishedYes

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Merkel Cell Carcinoma
Drug Therapy
Small Cell Lung Carcinoma
Drug Combinations
Combination Drug Therapy
Neoplasm Metastasis
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Feun, L. G., Savaraj, N., Legha, S. S., Silva, E. G., Benjamin, R. S., & Burgess, M. A. (1988). Chemotherapy for metastatic Merkel cell carcinoma: Review of the M.D. Anderson Hospital's experience. Cancer, 62(4), 683-685.

Chemotherapy for metastatic Merkel cell carcinoma : Review of the M.D. Anderson Hospital's experience. / Feun, Lynn G; Savaraj, Niramol; Legha, S. S.; Silva, E. G.; Benjamin, R. S.; Burgess, M. A.

In: Cancer, Vol. 62, No. 4, 01.01.1988, p. 683-685.

Research output: Contribution to journalArticle

Feun, LG, Savaraj, N, Legha, SS, Silva, EG, Benjamin, RS & Burgess, MA 1988, 'Chemotherapy for metastatic Merkel cell carcinoma: Review of the M.D. Anderson Hospital's experience', Cancer, vol. 62, no. 4, pp. 683-685.
Feun, Lynn G ; Savaraj, Niramol ; Legha, S. S. ; Silva, E. G. ; Benjamin, R. S. ; Burgess, M. A. / Chemotherapy for metastatic Merkel cell carcinoma : Review of the M.D. Anderson Hospital's experience. In: Cancer. 1988 ; Vol. 62, No. 4. pp. 683-685.
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