TY - JOUR
T1 - Chemotactic defects in severe combined immunodeficiency
AU - Pahwa, Savita G.
AU - Smithwick, Elizabeth M.
AU - Grimes, Elena R.
AU - O'Reilly, Richard J.
AU - Pahwa, Rajendra N.
AU - Good, Robert A.
N1 - Funding Information:
From the Department of Pediatrics, Clinical Immunobiology, Memorial Sloan-Kettering Cancer Center, and Department of Pediatrics, New York Hospital-Cornell Medical Center. Supported by National Foundation-March of Dimes, National Institutes of Health Grants CA-05826, CA-19267-01A1, AI-11843, and the Zelda Radow Weintraub Cancer Fund. Presented in part at the annual meeting of the American Pediatric Society, Society for Pediatric Research, April 29, 1976, St. Louis, MO. *Reprint address: Memorial Hospital, 1275 York Ave., New York, NY 10021,
PY - 1978/1
Y1 - 1978/1
N2 - Cellular and humoral components of leukotaxis were studied serially in four male infants with severe combined immunodeficiency disease. Two of the four, both lacking B and T cells initially, had a significant defect in neutrophil and monocyte chemotaxis. The other two, who had a high number of immunoglobulin-bearing cells (B cells), did not have these cellular abnormalities. In contrast, defective generation of chemotactic factor following endotoxin activation was observed in all patients. The defects were corrected coincident with or soon after successful engraftment of either bone marrow or fetal tissues. The reported deficiencies may be another manifestation of the heterogeneity in SCID.
AB - Cellular and humoral components of leukotaxis were studied serially in four male infants with severe combined immunodeficiency disease. Two of the four, both lacking B and T cells initially, had a significant defect in neutrophil and monocyte chemotaxis. The other two, who had a high number of immunoglobulin-bearing cells (B cells), did not have these cellular abnormalities. In contrast, defective generation of chemotactic factor following endotoxin activation was observed in all patients. The defects were corrected coincident with or soon after successful engraftment of either bone marrow or fetal tissues. The reported deficiencies may be another manifestation of the heterogeneity in SCID.
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U2 - 10.1016/S0022-3476(78)80068-7
DO - 10.1016/S0022-3476(78)80068-7
M3 - Article
C2 - 338873
AN - SCOPUS:0017883070
VL - 92
SP - 43
EP - 50
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 1
ER -