Chemosensors for the marine toxin saxitoxin

Robert E. Gawley, Sandra Pinet, Claudia M. Cardona, Probal K. Datta, Tong Ren, Wayne C. Guida, Jason Nydick, Roger M. Leblanc

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Eleven anthracylmethyl crown ethers have been synthesized and evaluated as fluorescence sensors for the marine toxin saxitoxin. Fluorescence enhancement data are consistent with a 1:1 binding complex for all crowns. The binding constants are in the range of 104 M-1 in ammonium phosphate buffer (pH 7.1) in 80% ethanol solvent. Selectivity for sensing saxitoxin versus several organic analytes has been demonstrated for the first time. Possible modes of binding are presented, and relevance to saxitoxin monitoring programs are discussed.

Original languageEnglish (US)
Pages (from-to)13448-13453
Number of pages6
JournalJournal of the American Chemical Society
Issue number45
StatePublished - Nov 13 2002

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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