Chemoprophylaxis with cefoxitin and cephalothin in orthopedic surgery: A comparison

M. B. Rosenfeld, J. Campos, K. R. Ratzan, I. Uredo

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Forty-eight patients who underwent elective hip or knee surgery were randomly divided into two groups. A total of 22 patients received a single 1-g preoperative bolus of cefoxitin, and 26 patients received a single 1-g preoperative dose of cephalothin. At various time intervals, serum and bone samples were taken during the operative procedure. Our data indicated that whereas serum levels of cefoxitin and cephalothin were maintained for at least 2 h at levels capable of inhibiting most gram-positive cocci and many gram-negative rods, bone levels of cefoxitin only were sustained at therapeutic levels, and those of cephalothin showed a rather rapid decay over a 2-h period. Moreover, in only 58% of the entire cephalothin-treated group were bone levels detectable and then only at a concentration that would inhibit gram-positive cocci. No significant morbidity was observed in either treatment group.

Original languageEnglish (US)
Pages (from-to)826-830
Number of pages5
JournalAntimicrobial agents and chemotherapy
Issue number5
StatePublished - 1981

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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