Chemonucleolysis with disease: Technique, results, case reports

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


This report details observations made while the author was developing personal experience with a method for intradiscal injections in the lumbar spine using chymopapain, in preparation for participation in a subsequent double blind study. Thirty patients were injected with the enzyme according to a standardized protocol, which included discography. All patients were candidates for surgery for disc displacement. The overall rate of satisfactory symptomatic relief was 70% at an average follow up time of 11 months, and 21 of 30 patients returned to their previous employment.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
Issue number2
StatePublished - Jun 1976


  • Chemonucleolysis
  • Chymopapain
  • Intradiscal injection
  • Low-back pain

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Clinical Neurology


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