Chemonucleolysis with disease: Technique, results, case reports

Mark D. Brown

doi:10.1097/00007632-197606000-00005

Chemonucleolysis with disease: Technique, results, case reports

Mark D. Brown

Orthopaedics

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

This report details observations made while the author was developing personal experience with a method for intradiscal injections in the lumbar spine using chymopapain, in preparation for participation in a subsequent double blind study. Thirty patients were injected with the enzyme according to a standardized protocol, which included discography. All patients were candidates for surgery for disc displacement. The overall rate of satisfactory symptomatic relief was 70% at an average follow up time of 11 months, and 21 of 30 patients returned to their previous employment.

Original language	English (US)
Pages (from-to)	115-120
Number of pages	6
Journal	SPINE
Volume	1
Issue number	2
DOIs	https://doi.org/10.1097/00007632-197606000-00005
State	Published - Jun 1976

Keywords

Chemonucleolysis
Chymopapain
Intradiscal injection
Low-back pain

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Clinical Neurology

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AB - This report details observations made while the author was developing personal experience with a method for intradiscal injections in the lumbar spine using chymopapain, in preparation for participation in a subsequent double blind study. Thirty patients were injected with the enzyme according to a standardized protocol, which included discography. All patients were candidates for surgery for disc displacement. The overall rate of satisfactory symptomatic relief was 70% at an average follow up time of 11 months, and 21 of 30 patients returned to their previous employment.

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KW - Chymopapain

KW - Intradiscal injection

KW - Low-back pain

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Chemonucleolysis with disease: Technique, results, case reports

Abstract

Keywords

ASJC Scopus subject areas

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