Chemo- and Regioselective Synthesis of Alkynyl Cyclobutanes by Visible Light Photocatalysis

Chao Zhou, Tao Lei, Xiang Zhu Wei, Zan Liu, Bin Chen, Vaidhyanathan Ramamurthy, Chen Ho Tung, Li Zhu Wu

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Here is the first visible light catalytic intermolecular cross [2 + 2] cycloaddition of enynes with alkenes to alkynyl cyclobutanes established with good functional group tolerance and high reaction efficiency and selectivity. Detailed studies reveal that enynes, including nonaromatic ones, can be sensitized by fac-Ir(ppy)3 via an energy transfer pathway. Addition of the Lewis acid PPh3AuNTf2 enables the cross photo[2 + 2] cycloaddition reaction to take place under both direct visible light irradiation or sensitization by Ru(bpy)3(PF6)2.

Original languageEnglish (US)
Pages (from-to)6808-6811
Number of pages4
JournalOrganic Letters
Volume20
Issue number21
DOIs
StatePublished - Nov 2 2018

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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