Chemistry in confined spaces: High-energy conformer of a piperidine derivative is favored within a water-soluble capsuleplex

Mintu Porel, Nithyanandhan Jayaraj, S. Raghothama, V. Ramamurthy

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Propyloxy-substituted piperidine in solution adopts a conformation in which its alkoxy group is equatorially positioned. Surprisingly, two conformers of it that do not interconvert in the NMR time scale at room temperature have been found within an octa-acid capsule. The serendipitous finding of the axial conformer of propyloxy-substituted piperidine within a supramolecular capsule highlights the value of confined spaces in physical organic chemistry.

Original languageEnglish (US)
Pages (from-to)4544-4547
Number of pages4
JournalOrganic letters
Volume12
Issue number20
DOIs
StatePublished - Oct 15 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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