Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions

J. P. Bearinger, S. Terrettaz, R. Michel, N. Tirelli, H. Vogel, M. Textor, J. A. Hubbell

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

Alkanethiolates have been widely used as chemisorbates to modify gold surfaces, in spite of their relatively poor oxidative stability. We introduce gold-chemisorbing block copolymers bearing an anchoring block of poly(propylene sulphide) (PPS), selected in the expectation of greater stability. These materials offer a more robust approach to surface modification of gold. As an example, a triblock copolymer with poly(ethylene glycol) (PEG) was selected, with the goal of minimizing biological adsorption and adhesion. The copolymer PEG17-bl-PPS25-bl-PEG9 chemisorbed to form a dense monolayer of 2.6 ± 26 ng cm-2, ∼2.2 nm thick. The copolymeric adlayer was much more stable to oxidation than commonly used alkanethiolates. Its presence greatly reduced protein adsorption (>95%), even after exposure to whole blood serum (>55 mg ml-1), as well as cell adhesion over long culture durations (>97%). PPS-containing copolymers are and attractive alternative to alkanethiolates, and PEG-bl-PPS-bl-PEG presents a powerful example for use in biodiagnostic and bioanalytical devices.

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalNature Materials
Volume2
Issue number4
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

Fingerprint

polypropylene
Polyethylene glycols
sulfides
Polypropylenes
copolymers
Copolymers
Gold
gold
propylene
adhesion
blood serum
Block copolymers
Propylene
adsorption
Bearings (structural)
interactions
block copolymers
Adsorption
glycols
Cell adhesion

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Bearinger, J. P., Terrettaz, S., Michel, R., Tirelli, N., Vogel, H., Textor, M., & Hubbell, J. A. (2003). Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions. Nature Materials, 2(4), 259-264. https://doi.org/10.1038/nmat851

Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions. / Bearinger, J. P.; Terrettaz, S.; Michel, R.; Tirelli, N.; Vogel, H.; Textor, M.; Hubbell, J. A.

In: Nature Materials, Vol. 2, No. 4, 01.04.2003, p. 259-264.

Research output: Contribution to journalArticle

Bearinger, JP, Terrettaz, S, Michel, R, Tirelli, N, Vogel, H, Textor, M & Hubbell, JA 2003, 'Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions', Nature Materials, vol. 2, no. 4, pp. 259-264. https://doi.org/10.1038/nmat851
Bearinger JP, Terrettaz S, Michel R, Tirelli N, Vogel H, Textor M et al. Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions. Nature Materials. 2003 Apr 1;2(4):259-264. https://doi.org/10.1038/nmat851
Bearinger, J. P. ; Terrettaz, S. ; Michel, R. ; Tirelli, N. ; Vogel, H. ; Textor, M. ; Hubbell, J. A. / Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions. In: Nature Materials. 2003 ; Vol. 2, No. 4. pp. 259-264.
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