Chemically tunable lensing of stimuli-responsive hydrogel microdomes

Jason D. Ehrick, Sean Stokes, Stephanie Bachas-Daunert, Elizabeth A. Moschou, Sapna K. Deo, Leonidas G. Bachas, Sylvia Daunert

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Genetically engineered protein calmodulin (CaM) was utilized as a model hinge-motion binding protein for the development of chemically tunable microlenses. An alternative method for the creation of microlenses by providing a one-step fabrication method for chemically tunable stimuli-responsive hydrogen microdomes were presented. The applications of these microlenses in the field of micro-optics and biosensing were also demonstrated. Stimuli-responsive hydrogels are applied in bioseparations, sensors, actuators, drug delivery, and biomedicine, because of their ability to respond reversible to an external stimulus that creates a measurable effect on the properties of the material. The practical applications of these microlenses are restricted to multimeric proteins that binds to multiple recognition elements on the surface of the hydrogel, thus altering the crosslinking of the surface of the microlens.

Original languageEnglish (US)
Pages (from-to)4024-4027
Number of pages4
JournalAdvanced Materials
Volume19
Issue number22
DOIs
StatePublished - Nov 19 2007
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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