Chemical shift imaging at 3 Tesla

Effect of echo time on assessing bone marrow abnormalities

F. Del Grande, Ty Subhawong, A. Flammang, L. M. Fayad

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: Our purpose is to test the effect of varied in-phase (IP) and opposed-phase (OP) sequence order on characterizing marrow signal changes at 3T. Materials and methods: The study was HIPAA compliant and IRB approved. Informed consent was waived. At 3T, IP and OP sequences were acquired in three patients with biopsy-proven osteosarcomas, using two methods: approach 1 (OP acquisition before IP acquisition) and approach 2 (OP after IP). Signal intensity (SI) measurements in 12 locations of biopsy-proven osteosarcoma and in six locations with normal bone marrow were performed independently by two experienced musculoskeletal radiologists. The signal intensity ratio (SIR) was measured within the marrow where there was T1 signal lower than skeletal muscle. A SIR∈<∈20 % on the OP compared with IP imaging was considered positive for marrow replacement, while SIR∈>∈= 20 % was considered negative. Interobserver agreement was measured by the Lin concordance correlation coefficient (CCC). Results: In 75 % (18/24) of locations within the biopsy-proven tumors, the SIR was >20 % (SI drop more than 20 % in OP compared to IP) using approach 2 and in 100 % (24/24) of the locations the SIR was <20 % (SI drop less than 20 % in OP compared to IP) using approach 1, indicating a high percentage of false-negative results by approach 2, and no false-negative results with approach 1. There was good agreement between observer measurement (CCC∈=∈0.96). Conclusions: At 3T, the OP sequence should be acquired prior to the IP sequence, because susceptibility artifacts on a later-acquired OP sequence may lead to an erroneous interpretation of marrow signal abnormalities.

Original languageEnglish
Pages (from-to)1139-1147
Number of pages9
JournalSkeletal Radiology
Volume43
Issue number8
DOIs
StatePublished - Jan 1 2014

Fingerprint

Bone Marrow
Magnetic Resonance Imaging
Osteosarcoma
Biopsy
Health Insurance Portability and Accountability Act
Research Ethics Committees
Informed Consent
Artifacts
Skeletal Muscle
Neoplasms

Keywords

  • 3 Tesla MRI
  • Bone marrow
  • Chemical shift imaging
  • Echo time

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Chemical shift imaging at 3 Tesla : Effect of echo time on assessing bone marrow abnormalities. / Del Grande, F.; Subhawong, Ty; Flammang, A.; Fayad, L. M.

In: Skeletal Radiology, Vol. 43, No. 8, 01.01.2014, p. 1139-1147.

Research output: Contribution to journalArticle

Del Grande, F. ; Subhawong, Ty ; Flammang, A. ; Fayad, L. M. / Chemical shift imaging at 3 Tesla : Effect of echo time on assessing bone marrow abnormalities. In: Skeletal Radiology. 2014 ; Vol. 43, No. 8. pp. 1139-1147.
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abstract = "Objective: Our purpose is to test the effect of varied in-phase (IP) and opposed-phase (OP) sequence order on characterizing marrow signal changes at 3T. Materials and methods: The study was HIPAA compliant and IRB approved. Informed consent was waived. At 3T, IP and OP sequences were acquired in three patients with biopsy-proven osteosarcomas, using two methods: approach 1 (OP acquisition before IP acquisition) and approach 2 (OP after IP). Signal intensity (SI) measurements in 12 locations of biopsy-proven osteosarcoma and in six locations with normal bone marrow were performed independently by two experienced musculoskeletal radiologists. The signal intensity ratio (SIR) was measured within the marrow where there was T1 signal lower than skeletal muscle. A SIR∈<∈20 {\%} on the OP compared with IP imaging was considered positive for marrow replacement, while SIR∈>∈= 20 {\%} was considered negative. Interobserver agreement was measured by the Lin concordance correlation coefficient (CCC). Results: In 75 {\%} (18/24) of locations within the biopsy-proven tumors, the SIR was >20 {\%} (SI drop more than 20 {\%} in OP compared to IP) using approach 2 and in 100 {\%} (24/24) of the locations the SIR was <20 {\%} (SI drop less than 20 {\%} in OP compared to IP) using approach 1, indicating a high percentage of false-negative results by approach 2, and no false-negative results with approach 1. There was good agreement between observer measurement (CCC∈=∈0.96). Conclusions: At 3T, the OP sequence should be acquired prior to the IP sequence, because susceptibility artifacts on a later-acquired OP sequence may lead to an erroneous interpretation of marrow signal abnormalities.",
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