Chemical neurotoxicity: Detection and analysis in organotypic cultures of sensory and motor systems

P. S. Spencer, S. M. Crain, M. B. Bornstein, E. R. Peterson, T. Van De Water

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Screening of chemical substances for human neurotoxic (and therapeutic) properties may be carried out with the aid of organotypic tissue cultures composed of foetal explants of mouse sensory and neuromuscular tissues that develop in vitro their characteristic cytoarchitectural and functional organization. Supporting this statement is a wealth of studies describing a range of specific, chemically-induced responses in organotypic neural cultures that parallel changes induced in the nervous system of humans and animals.

Original languageEnglish (US)
Pages (from-to)539-544
Number of pages6
JournalFood and Chemical Toxicology
Volume24
Issue number6-7
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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    Spencer, P. S., Crain, S. M., Bornstein, M. B., Peterson, E. R., & Van De Water, T. (1986). Chemical neurotoxicity: Detection and analysis in organotypic cultures of sensory and motor systems. Food and Chemical Toxicology, 24(6-7), 539-544. https://doi.org/10.1016/0278-6915(86)90110-9