Chemical inhibition method for alkaline phosphatase isoenzymes in human serum

D. O'Carroll, B. E. Statland, Bernard W Steele, M. D. Burke

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The authors adapted a chemical inhibition procedure using L phenylalanine and urea as specific inhibitors to quantitate the activities of bone, liver, and intestinal alkaline phosphatase (ALP) isoenzymes in human serum. The results of this assay were compared with electrophoretic separation, gamma glutamyl transpeptidase activity, and the clinical setting in a group of patients with elevated total ALP activity. In addition, expected ranges of serum ALP isoenzymes for healthy young men and also for a geriatric population are presented.

Original languageEnglish
Pages (from-to)564-572
Number of pages9
JournalAmerican Journal of Clinical Pathology
Volume63
Issue number4
StatePublished - Dec 1 1975
Externally publishedYes

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Isoenzymes
Alkaline Phosphatase
Serum
gamma-Glutamyltransferase
Phenylalanine
Geriatrics
Urea
Bone and Bones
Liver
Population

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

O'Carroll, D., Statland, B. E., Steele, B. W., & Burke, M. D. (1975). Chemical inhibition method for alkaline phosphatase isoenzymes in human serum. American Journal of Clinical Pathology, 63(4), 564-572.

Chemical inhibition method for alkaline phosphatase isoenzymes in human serum. / O'Carroll, D.; Statland, B. E.; Steele, Bernard W; Burke, M. D.

In: American Journal of Clinical Pathology, Vol. 63, No. 4, 01.12.1975, p. 564-572.

Research output: Contribution to journalArticle

O'Carroll, D, Statland, BE, Steele, BW & Burke, MD 1975, 'Chemical inhibition method for alkaline phosphatase isoenzymes in human serum', American Journal of Clinical Pathology, vol. 63, no. 4, pp. 564-572.
O'Carroll, D. ; Statland, B. E. ; Steele, Bernard W ; Burke, M. D. / Chemical inhibition method for alkaline phosphatase isoenzymes in human serum. In: American Journal of Clinical Pathology. 1975 ; Vol. 63, No. 4. pp. 564-572.
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