TY - JOUR
T1 - Chemical and electrical synaptic interactions among taste bud cells
AU - Roper, Stephen D.
N1 - Funding Information:
This work has been supported over the recent years by NIH grants R01DC018733 , R01DC017303 , R01DC006308 , R01DC014420 , and R01DC007630 .
Funding Information:
I would like to acknowledge and thank S A Simon (Duke) and N Chaudhari (U Miami) for their helpful comments and suggestions. I dedicate this article to Douglas A Ewald, my friend and former collaborator at Colorado State University. Doug helped pioneer the lingual slice preparation for studying taste buds ex vivo and was the first to record cell?cell interactions between taste cells, described in the above review. Doug passed away in June 2020. This work has been supported over the recent years by NIH grants R01DC018733, R01DC017303, R01DC006308, R01DC014420, and R01DC007630.
Publisher Copyright:
© 2021 Elsevier Ltd
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/4
Y1 - 2021/4
N2 - Chemical synapses between taste cells were first proposed based on electron microscopy of fish taste buds. Subsequently, researchers found considerable evidence for electrical coupling in fish, amphibian, and possibly mammalian taste buds. The development lingual slice and isolated cell preparations allowed detailed investigations of cell‐cell interactions, both chemical and electrical, in taste buds. The identification of serotonin and ATP as taste neurotransmitters focused attention onto chemical synaptic interactions between taste cells and research on electrical coupling faded. Findings from Ca2+ imaging, electrophysiology, and molecular biology indicate that several neurotransmitters, including ATP, serotonin, GABA, acetylcholine, and norepinephrine, are secreted by taste cells and exert paracrine interactions in taste buds. Most work has been done on interactions between Type II and Type III taste cells. This brief review follows the trail of studies on cell–cell interactions in taste buds, from the initial ultrastructural observations to the most recent optogenetic manipulations.
AB - Chemical synapses between taste cells were first proposed based on electron microscopy of fish taste buds. Subsequently, researchers found considerable evidence for electrical coupling in fish, amphibian, and possibly mammalian taste buds. The development lingual slice and isolated cell preparations allowed detailed investigations of cell‐cell interactions, both chemical and electrical, in taste buds. The identification of serotonin and ATP as taste neurotransmitters focused attention onto chemical synaptic interactions between taste cells and research on electrical coupling faded. Findings from Ca2+ imaging, electrophysiology, and molecular biology indicate that several neurotransmitters, including ATP, serotonin, GABA, acetylcholine, and norepinephrine, are secreted by taste cells and exert paracrine interactions in taste buds. Most work has been done on interactions between Type II and Type III taste cells. This brief review follows the trail of studies on cell–cell interactions in taste buds, from the initial ultrastructural observations to the most recent optogenetic manipulations.
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U2 - 10.1016/j.cophys.2020.12.004
DO - 10.1016/j.cophys.2020.12.004
M3 - Review article
AN - SCOPUS:85099800988
VL - 20
SP - 118
EP - 125
JO - Current Opinion in Physiology
JF - Current Opinion in Physiology
SN - 2468-8681
ER -