Characterizing healthy samples for studies of human cognitive aging

David S. Geldmacher, Bonnie E. Levin, Clinton B. Wright

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Characterizing the cognitive declines associated with aging, and differentiating them from the effects of disease in older adults, are important goals for human neuroscience researchers. This is also an issue of public health urgency in countries with rapidly aging populations. Progress toward understanding cognitive aging is complicated by numerous factors. Researchers interested in cognitive changes in healthy older adults need to consider these complexities when they design and interpret studies. This paper addresses important factors in study design, patient demographics, co-morbid and incipient medical conditions, and assessment instruments that will allow researchers to optimize the characterization of healthy participants and produce meaningful and generalizable research outcomes from studies of cognitive aging. Application of knowledge from well-designed studies should be useful in clinical settings to facilitate the earliest possible recognition of disease and guide appropriate interventions to best meet the needs of the affected individual and public health priorities.

Original languageEnglish (US)
Article numberArticle 23
JournalFrontiers in Aging Neuroscience
Volume4
Issue numberSEP
DOIs
StatePublished - 2012

Keywords

  • Cognitive aging
  • Research methods
  • Sample heterogeneity
  • Screening instruments
  • Subject selection

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience

Fingerprint Dive into the research topics of 'Characterizing healthy samples for studies of human cognitive aging'. Together they form a unique fingerprint.

  • Cite this