Characterization of the LH response to luteinizing hormone-releasing hormone (LH-RH) in isolated and multiple tropic hormone deficiencies

G. A. Medeiros-Neto, S. P.A. Toledo, A. A. Pupo, M. S. Sucupira, F. Fraige-Filho, E. Mattar, A. J. Kastin, A. V. Schally

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13 Scopus citations


Synthetic LH RH was infused in 2 siblings with multiple tropic hormone deficiencies and dwarfism and another patient with monotropic deficiency of hGH. A minimal response in plasma LH levels was observed in the patients with idiopathic hypopituitarism. The other individual with isolated hGH deficiency, however, showed an abrupt increase in plasma LH level with a characteristic time course (peak at 30 min after the injection). When LH RH was given by intravenous drip over a period of 8 hr, followed by an injection of 200 μg of synthetic LH RH, plasma LH in the patients with multiple deficiencies rose from a basal level of 6.9 mIU/ml to 10.8 mIU/ml (case one) and 2.5 mIU/ml to 8.3 mIU/ml (case two). The absence of a significant response after a single injection of LH RH could be the result of chronic deprivation of LH RH due to a hypothalamic lesion in these patients.

Original languageEnglish (US)
Pages (from-to)972-976
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Issue number6
StatePublished - Dec 1973
Externally publishedYes


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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