Characterization of the LH response to luteinizing hormone-releasing hormone (LH-RH) in isolated and multiple tropic hormone deficiencies

G. A. Medeiros-Neto; S. P.A. Toledo; A. A. Pupo; M. S. Sucupira; F. Fraige-Filho; E. Mattar; A. J. Kastin; A. V. Schally

doi:10.1210/jcem-37-6-972

Characterization of the LH response to luteinizing hormone-releasing hormone (LH-RH) in isolated and multiple tropic hormone deficiencies

G. A. Medeiros-Neto, S. P.A. Toledo, A. A. Pupo, M. S. Sucupira, F. Fraige-Filho, E. Mattar, A. J. Kastin, A. V. Schally

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Synthetic LH RH was infused in 2 siblings with multiple tropic hormone deficiencies and dwarfism and another patient with monotropic deficiency of hGH. A minimal response in plasma LH levels was observed in the patients with idiopathic hypopituitarism. The other individual with isolated hGH deficiency, however, showed an abrupt increase in plasma LH level with a characteristic time course (peak at 30 min after the injection). When LH RH was given by intravenous drip over a period of 8 hr, followed by an injection of 200 μg of synthetic LH RH, plasma LH in the patients with multiple deficiencies rose from a basal level of 6.9 mIU/ml to 10.8 mIU/ml (case one) and 2.5 mIU/ml to 8.3 mIU/ml (case two). The absence of a significant response after a single injection of LH RH could be the result of chronic deprivation of LH RH due to a hypothalamic lesion in these patients.

Original language	English (US)
Pages (from-to)	972-976
Number of pages	5
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	37
Issue number	6
DOIs	https://doi.org/10.1210/jcem-37-6-972
State	Published - Dec 1973
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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Medeiros-Neto, G. A., Toledo, S. P. A., Pupo, A. A., Sucupira, M. S., Fraige-Filho, F., Mattar, E., Kastin, A. J., & Schally, A. V. (1973). Characterization of the LH response to luteinizing hormone-releasing hormone (LH-RH) in isolated and multiple tropic hormone deficiencies. Journal of Clinical Endocrinology and Metabolism, 37(6), 972-976. https://doi.org/10.1210/jcem-37-6-972

Characterization of the LH response to luteinizing hormone-releasing hormone (LH-RH) in isolated and multiple tropic hormone deficiencies. / Medeiros-Neto, G. A.; Toledo, S. P.A.; Pupo, A. A.; Sucupira, M. S.; Fraige-Filho, F.; Mattar, E.; Kastin, A. J.; Schally, A. V.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 37, No. 6, 12.1973, p. 972-976.

Research output: Contribution to journal › Article › peer-review

Medeiros-Neto, GA, Toledo, SPA, Pupo, AA, Sucupira, MS, Fraige-Filho, F, Mattar, E, Kastin, AJ & Schally, AV 1973, 'Characterization of the LH response to luteinizing hormone-releasing hormone (LH-RH) in isolated and multiple tropic hormone deficiencies', Journal of Clinical Endocrinology and Metabolism, vol. 37, no. 6, pp. 972-976. https://doi.org/10.1210/jcem-37-6-972

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abstract = "Synthetic LH RH was infused in 2 siblings with multiple tropic hormone deficiencies and dwarfism and another patient with monotropic deficiency of hGH. A minimal response in plasma LH levels was observed in the patients with idiopathic hypopituitarism. The other individual with isolated hGH deficiency, however, showed an abrupt increase in plasma LH level with a characteristic time course (peak at 30 min after the injection). When LH RH was given by intravenous drip over a period of 8 hr, followed by an injection of 200 μg of synthetic LH RH, plasma LH in the patients with multiple deficiencies rose from a basal level of 6.9 mIU/ml to 10.8 mIU/ml (case one) and 2.5 mIU/ml to 8.3 mIU/ml (case two). The absence of a significant response after a single injection of LH RH could be the result of chronic deprivation of LH RH due to a hypothalamic lesion in these patients.",

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AU - Pupo, A. A.

AU - Sucupira, M. S.

AU - Fraige-Filho, F.

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AU - Kastin, A. J.

AU - Schally, A. V.

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N2 - Synthetic LH RH was infused in 2 siblings with multiple tropic hormone deficiencies and dwarfism and another patient with monotropic deficiency of hGH. A minimal response in plasma LH levels was observed in the patients with idiopathic hypopituitarism. The other individual with isolated hGH deficiency, however, showed an abrupt increase in plasma LH level with a characteristic time course (peak at 30 min after the injection). When LH RH was given by intravenous drip over a period of 8 hr, followed by an injection of 200 μg of synthetic LH RH, plasma LH in the patients with multiple deficiencies rose from a basal level of 6.9 mIU/ml to 10.8 mIU/ml (case one) and 2.5 mIU/ml to 8.3 mIU/ml (case two). The absence of a significant response after a single injection of LH RH could be the result of chronic deprivation of LH RH due to a hypothalamic lesion in these patients.

AB - Synthetic LH RH was infused in 2 siblings with multiple tropic hormone deficiencies and dwarfism and another patient with monotropic deficiency of hGH. A minimal response in plasma LH levels was observed in the patients with idiopathic hypopituitarism. The other individual with isolated hGH deficiency, however, showed an abrupt increase in plasma LH level with a characteristic time course (peak at 30 min after the injection). When LH RH was given by intravenous drip over a period of 8 hr, followed by an injection of 200 μg of synthetic LH RH, plasma LH in the patients with multiple deficiencies rose from a basal level of 6.9 mIU/ml to 10.8 mIU/ml (case one) and 2.5 mIU/ml to 8.3 mIU/ml (case two). The absence of a significant response after a single injection of LH RH could be the result of chronic deprivation of LH RH due to a hypothalamic lesion in these patients.

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Characterization of the LH response to luteinizing hormone-releasing hormone (LH-RH) in isolated and multiple tropic hormone deficiencies

Abstract

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