Characterization of the LH response to luteinizing hormone releasing hormone (LH RH) in isolated and multiple tropic hormone deficiencies

G. A. Medeiros Neto, S. P A Toledo, A. A. Pupo, M. S. Sucupira, F. Fraige-Filho, E. Mattar, A. J. Kastin, Andrew V Schally

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Synthetic LH RH was infused in 2 siblings with multiple tropic hormone deficiencies and dwarfism and another patient with monotropic deficiency of hGH. A minimal response in plasma LH levels was observed in the patients with idiopathic hypopituitarism. The other individual with isolated hGH deficiency, however, showed an abrupt increase in plasma LH level with a characteristic time course (peak at 30 min after the injection). When LH RH was given by intravenous drip over a period of 8 hr, followed by an injection of 200 μg of synthetic LH RH, plasma LH in the patients with multiple deficiencies rose from a basal level of 6.9 mIU/ml to 10.8 mIU/ml (case one) and 2.5 mIU/ml to 8.3 mIU/ml (case two). The absence of a significant response after a single injection of LH RH could be the result of chronic deprivation of LH RH due to a hypothalamic lesion in these patients.

Original languageEnglish
Pages (from-to)972-976
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume37
Issue number6
StatePublished - Dec 1 1973
Externally publishedYes

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Tropics
Gonadotropin-Releasing Hormone
Hormones
Plasmas
Injections
Dwarfism
Hypopituitarism
Intravenous Infusions
Siblings

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Characterization of the LH response to luteinizing hormone releasing hormone (LH RH) in isolated and multiple tropic hormone deficiencies. / Medeiros Neto, G. A.; Toledo, S. P A; Pupo, A. A.; Sucupira, M. S.; Fraige-Filho, F.; Mattar, E.; Kastin, A. J.; Schally, Andrew V.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 37, No. 6, 01.12.1973, p. 972-976.

Research output: Contribution to journalArticle

Medeiros Neto, GA, Toledo, SPA, Pupo, AA, Sucupira, MS, Fraige-Filho, F, Mattar, E, Kastin, AJ & Schally, AV 1973, 'Characterization of the LH response to luteinizing hormone releasing hormone (LH RH) in isolated and multiple tropic hormone deficiencies', Journal of Clinical Endocrinology and Metabolism, vol. 37, no. 6, pp. 972-976.
Medeiros Neto, G. A. ; Toledo, S. P A ; Pupo, A. A. ; Sucupira, M. S. ; Fraige-Filho, F. ; Mattar, E. ; Kastin, A. J. ; Schally, Andrew V. / Characterization of the LH response to luteinizing hormone releasing hormone (LH RH) in isolated and multiple tropic hormone deficiencies. In: Journal of Clinical Endocrinology and Metabolism. 1973 ; Vol. 37, No. 6. pp. 972-976.
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abstract = "Synthetic LH RH was infused in 2 siblings with multiple tropic hormone deficiencies and dwarfism and another patient with monotropic deficiency of hGH. A minimal response in plasma LH levels was observed in the patients with idiopathic hypopituitarism. The other individual with isolated hGH deficiency, however, showed an abrupt increase in plasma LH level with a characteristic time course (peak at 30 min after the injection). When LH RH was given by intravenous drip over a period of 8 hr, followed by an injection of 200 μg of synthetic LH RH, plasma LH in the patients with multiple deficiencies rose from a basal level of 6.9 mIU/ml to 10.8 mIU/ml (case one) and 2.5 mIU/ml to 8.3 mIU/ml (case two). The absence of a significant response after a single injection of LH RH could be the result of chronic deprivation of LH RH due to a hypothalamic lesion in these patients.",
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AU - Sucupira, M. S.

AU - Fraige-Filho, F.

AU - Mattar, E.

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