Synthetic LH RH was infused in 2 siblings with multiple tropic hormone deficiencies and dwarfism and another patient with monotropic deficiency of hGH. A minimal response in plasma LH levels was observed in the patients with idiopathic hypopituitarism. The other individual with isolated hGH deficiency, however, showed an abrupt increase in plasma LH level with a characteristic time course (peak at 30 min after the injection). When LH RH was given by intravenous drip over a period of 8 hr, followed by an injection of 200 μg of synthetic LH RH, plasma LH in the patients with multiple deficiencies rose from a basal level of 6.9 mIU/ml to 10.8 mIU/ml (case one) and 2.5 mIU/ml to 8.3 mIU/ml (case two). The absence of a significant response after a single injection of LH RH could be the result of chronic deprivation of LH RH due to a hypothalamic lesion in these patients.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Clinical Biochemistry
- Biochemistry, medical