Characterization of Plasmodium vivax transmission-blocking activity in low to moderate malaria transmission settings of the Colombian Pacific Coast

Myriam Arévalo-Herrera, Yezid Solarte, Leonardo Rocha, Diego Álvarez, John C. Beier, Sócrates Herrera

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Malaria infection induces antibodies capable of suppressing the infectivity of gametocytes and gametes, however, little is known about the duration of the antibody response, the parasite specificity, and the role of complement. We report the analyses of the transmission-blocking (TB) activity of sera collected from 105 Plasmodium vivax-infected and 44 non-infected individuals from a malaria endemic region of Colombia, using a membrane feeding assay in Anopheles albimanus mosquitoes. In infected donors we found that TB activity was antibody dose dependent (35%), lasted for 2-4 months after infection, and in 70% of the cases different P. vivax wild isolates displayed differential susceptibility to blocking antibodies. Additionally, in a number of assays TB was complement-dependent. Twenty-seven percent of non-infected individuals presented TB activity that correlated with antibody titers. Studies here provide preliminary data on factors of great importance for further work on the development of TB vaccines.

Original languageEnglish (US)
Pages (from-to)71-77
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume84
Issue number2 S
DOIs
StatePublished - Feb 2011

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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