Characterization of neural activity recorded from the descending tracts of the rat spinal cord

Abhishek Prasad, Mesut Sahin

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A multi-electrode array (MEA) was implanted in the dorsolateral funiculus of the cervical spinal cord to record descending information during behavior in freely moving rats. Neural signals were characterized in terms of frequency and information content. Frequency analysis revealed components both at the range of local field potentials and multi-unit activity. Coherence between channels decreased steadily with inter-contact distance and frequency suggesting greater spatial selectivity for multi-unit activity compared to local field potentials. Principal component analysis (PCA) extracted multiple channels of neural activity with patterns that correlated to the behavior, indicating multiple dimensionality of the signals. Two different behaviors involving the forelimbs, face cleaning and food reaching, generated neural signals through distinctly different combination of neural channels, which suggested that these two behaviors could readily be differentiated from recordings. This preliminary data demonstrated that descending spinal cord signals recorded with MEAs can be used to extract multiple channels of command control information and potentially be utilized as a means of communication in high level spinal cord injury subjects.

Original languageEnglish (US)
Article number21
JournalFrontiers in Neuroscience
Volume4
Issue numberJUN
DOIs
StatePublished - 2010

Keywords

  • Brain-computer
  • Neural interface
  • Rubrospinal tract

ASJC Scopus subject areas

  • Neuroscience(all)

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