Characterization of intraocular pressure increases and management strategies following treatment with fluocinolone acetonide intravitreal implants in the fame trials

Richard K Parrish, Peter A. Campochiaro, P. Andrew Pearson, Ken Green, Carlo E. Traverso

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVE: To compare elevated intraocular pressure (IOP) management and outcomes among patients with diabetic macular edema who received fluocinolone acetonide (FAc) implants versus sham-control treatment and explore the prior ocular steroid exposure impact on IOP outcomes. PATIENTS AND METHODS: Best-corrected visual acuity (BCVA) was measured using Early Treatment Diabetic Retinopathy Study charts or electronic VA testers. Goldmann applanation tonometry was used to measure IOP. RESULTS: Elevated IOP was more common in FAcversus sham control-treated patients. Medication, and less often trabeculoplasty or surgery, was used to lower IOP without affecting VA outcomes. No patient treated with 0.2 ?g/day FAc who received prior ocular steroid required IOP-lowering surgery. CONCLUSION: Elevated IOP may occur following FAc implant receipt; however, in the present study, it was manageable and did not impact vision outcomes. Patients previously treated with ocular steroid did not require IOP-lowering surgery following 0.2 ?g/day FAc implant administration.

Original languageEnglish (US)
Pages (from-to)426-435
Number of pages10
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume47
Issue number5
DOIs
StatePublished - May 1 2016

Fingerprint

Fluocinolone Acetonide
Intraocular Pressure
Steroids
Therapeutics
Trabeculectomy
Macular Edema
Manometry
Diabetic Retinopathy
Visual Acuity
Placebos

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Characterization of intraocular pressure increases and management strategies following treatment with fluocinolone acetonide intravitreal implants in the fame trials. / Parrish, Richard K; Campochiaro, Peter A.; Pearson, P. Andrew; Green, Ken; Traverso, Carlo E.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 47, No. 5, 01.05.2016, p. 426-435.

Research output: Contribution to journalArticle

@article{29fbe895421f44bb958dd2f57dd9f59c,
title = "Characterization of intraocular pressure increases and management strategies following treatment with fluocinolone acetonide intravitreal implants in the fame trials",
abstract = "BACKGROUND AND OBJECTIVE: To compare elevated intraocular pressure (IOP) management and outcomes among patients with diabetic macular edema who received fluocinolone acetonide (FAc) implants versus sham-control treatment and explore the prior ocular steroid exposure impact on IOP outcomes. PATIENTS AND METHODS: Best-corrected visual acuity (BCVA) was measured using Early Treatment Diabetic Retinopathy Study charts or electronic VA testers. Goldmann applanation tonometry was used to measure IOP. RESULTS: Elevated IOP was more common in FAcversus sham control-treated patients. Medication, and less often trabeculoplasty or surgery, was used to lower IOP without affecting VA outcomes. No patient treated with 0.2 ?g/day FAc who received prior ocular steroid required IOP-lowering surgery. CONCLUSION: Elevated IOP may occur following FAc implant receipt; however, in the present study, it was manageable and did not impact vision outcomes. Patients previously treated with ocular steroid did not require IOP-lowering surgery following 0.2 ?g/day FAc implant administration.",
author = "Parrish, {Richard K} and Campochiaro, {Peter A.} and Pearson, {P. Andrew} and Ken Green and Traverso, {Carlo E.}",
year = "2016",
month = "5",
day = "1",
doi = "10.3928/23258160-20160419-05",
language = "English (US)",
volume = "47",
pages = "426--435",
journal = "Ophthalmic Surgery Lasers and Imaging Retina",
issn = "2325-8160",
publisher = "Slack Incorporated",
number = "5",

}

TY - JOUR

T1 - Characterization of intraocular pressure increases and management strategies following treatment with fluocinolone acetonide intravitreal implants in the fame trials

AU - Parrish, Richard K

AU - Campochiaro, Peter A.

AU - Pearson, P. Andrew

AU - Green, Ken

AU - Traverso, Carlo E.

PY - 2016/5/1

Y1 - 2016/5/1

N2 - BACKGROUND AND OBJECTIVE: To compare elevated intraocular pressure (IOP) management and outcomes among patients with diabetic macular edema who received fluocinolone acetonide (FAc) implants versus sham-control treatment and explore the prior ocular steroid exposure impact on IOP outcomes. PATIENTS AND METHODS: Best-corrected visual acuity (BCVA) was measured using Early Treatment Diabetic Retinopathy Study charts or electronic VA testers. Goldmann applanation tonometry was used to measure IOP. RESULTS: Elevated IOP was more common in FAcversus sham control-treated patients. Medication, and less often trabeculoplasty or surgery, was used to lower IOP without affecting VA outcomes. No patient treated with 0.2 ?g/day FAc who received prior ocular steroid required IOP-lowering surgery. CONCLUSION: Elevated IOP may occur following FAc implant receipt; however, in the present study, it was manageable and did not impact vision outcomes. Patients previously treated with ocular steroid did not require IOP-lowering surgery following 0.2 ?g/day FAc implant administration.

AB - BACKGROUND AND OBJECTIVE: To compare elevated intraocular pressure (IOP) management and outcomes among patients with diabetic macular edema who received fluocinolone acetonide (FAc) implants versus sham-control treatment and explore the prior ocular steroid exposure impact on IOP outcomes. PATIENTS AND METHODS: Best-corrected visual acuity (BCVA) was measured using Early Treatment Diabetic Retinopathy Study charts or electronic VA testers. Goldmann applanation tonometry was used to measure IOP. RESULTS: Elevated IOP was more common in FAcversus sham control-treated patients. Medication, and less often trabeculoplasty or surgery, was used to lower IOP without affecting VA outcomes. No patient treated with 0.2 ?g/day FAc who received prior ocular steroid required IOP-lowering surgery. CONCLUSION: Elevated IOP may occur following FAc implant receipt; however, in the present study, it was manageable and did not impact vision outcomes. Patients previously treated with ocular steroid did not require IOP-lowering surgery following 0.2 ?g/day FAc implant administration.

UR - http://www.scopus.com/inward/record.url?scp=84983439216&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983439216&partnerID=8YFLogxK

U2 - 10.3928/23258160-20160419-05

DO - 10.3928/23258160-20160419-05

M3 - Article

C2 - 27183546

AN - SCOPUS:84983439216

VL - 47

SP - 426

EP - 435

JO - Ophthalmic Surgery Lasers and Imaging Retina

JF - Ophthalmic Surgery Lasers and Imaging Retina

SN - 2325-8160

IS - 5

ER -