Characteristics of complement receptor-bearing cells in the spleens of tumor-bearing mice

R. S. Epstein, D. M. Lopez, M. M. Sigel, G. D. Ross

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Abstract

In the course of mammary tumor development, a population of nylon nonadherent cells with CR appears in the spleens of tumor-bearing mice although none are ever detected in normal mice. These cells apparently arise in response to immunologic stimulation. In a series of studies we have further characterized subsets of T cells (CR+ and CR-) with regard to their responses to mitogens in the lymphocyte transformation assay. Nylon column nonadherent cells from the spleens of tumor-bearing mice were rosetted in a complement receptor assay using EAC rosetting, and CR+ cells were separated from CR- by centrifugation in a discontinuous Ficoll gradient. CR+ T cells responded strongly to PHA and Con A and in addition responded to LPS, an activity not usually associated with conventional T cells. In contrast, CR- T cells from tumor-burdened mice responded to PHA but failed to respond to Con A or LPS.

Original languageEnglish (US)
Pages (from-to)1524-1527
Number of pages4
JournalJournal of Immunology
Volume121
Issue number4
StatePublished - Dec 1 1978

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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