Characteristics and determinants of adiposity in pediatric cancer survivors

Tracie L Miller, Stuart R. Lipsitz, Gabriela Lopez-Mitnik, Andrea S. Hinkle, Louis S. Constine, M. Jacob Adams, Carol French, Cynthia Proukou, Amy Rovitelli, Steven E Lipshultz

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Background: Adiposity and the diseases associated with it, including cardiovascular disease, are emerging long-term complications of pediatric cancer survivors. Direct evaluations of adiposity and comparisons to contemporary controls that can differentiate recent trends in obesity from cancer-related treatments and sequelae are limited. Methods: We evaluated demographic, treatment, lifestyle, and endocrine factors at the time of dual-energy X-ray absorptiometry testing in 170 non-Hispanic white survivors and 71 sibling controls, and compared three measures of adiposity [body mass index (BMI), total body fat, and trunk fat]. For the survivors alone, we determined factors independently associated with BMI and body fat. Results: Survivors were at 12 years since diagnosis; 58% had leukemia or lymphoma. BMI did not differ between groups. Among males, body fat was greater in survivors than in controls (25.8% versus 20.7%; P = 0.007), as was trunk fat (26.7% versus 21.3%; P = 0.008). Total or trunk fat did not differ among females. Cholesterol, triglycerides, low-density lipoprotein cholesterol, and television viewing hours were higher among male survivors than in controls. Independent factors associated with higher BMI and total and trunk fat included any cranial radiation and television viewing hours, whereas prior treatment with cyclophosphamide was associated with lower BMI and body fat measures. Conclusions: Compared with siblings, male survivors have greater body fat and metabolic risks. Cranial irradiation and television hours are important risk factors for adiposity in pediatric cancer survivors. Impact: Pediatric cancer survivors should be carefully monitored for cardiovascular risk factors and sedentary lifestyles.

Original languageEnglish
Pages (from-to)2013-2022
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume19
Issue number8
DOIs
StatePublished - Aug 1 2010

Fingerprint

Adiposity
Survivors
Pediatrics
Adipose Tissue
Body Mass Index
Neoplasms
Television
Fats
Siblings
Body Weights and Measures
Cranial Irradiation
Sedentary Lifestyle
Second Primary Neoplasms
Photon Absorptiometry
LDL Cholesterol
Cyclophosphamide
Life Style
Lymphoma
Leukemia
Triglycerides

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Miller, T. L., Lipsitz, S. R., Lopez-Mitnik, G., Hinkle, A. S., Constine, L. S., Adams, M. J., ... Lipshultz, S. E. (2010). Characteristics and determinants of adiposity in pediatric cancer survivors. Cancer Epidemiology Biomarkers and Prevention, 19(8), 2013-2022. https://doi.org/10.1158/1055-9965.EPI-10-0163

Characteristics and determinants of adiposity in pediatric cancer survivors. / Miller, Tracie L; Lipsitz, Stuart R.; Lopez-Mitnik, Gabriela; Hinkle, Andrea S.; Constine, Louis S.; Adams, M. Jacob; French, Carol; Proukou, Cynthia; Rovitelli, Amy; Lipshultz, Steven E.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 19, No. 8, 01.08.2010, p. 2013-2022.

Research output: Contribution to journalArticle

Miller, TL, Lipsitz, SR, Lopez-Mitnik, G, Hinkle, AS, Constine, LS, Adams, MJ, French, C, Proukou, C, Rovitelli, A & Lipshultz, SE 2010, 'Characteristics and determinants of adiposity in pediatric cancer survivors', Cancer Epidemiology Biomarkers and Prevention, vol. 19, no. 8, pp. 2013-2022. https://doi.org/10.1158/1055-9965.EPI-10-0163
Miller TL, Lipsitz SR, Lopez-Mitnik G, Hinkle AS, Constine LS, Adams MJ et al. Characteristics and determinants of adiposity in pediatric cancer survivors. Cancer Epidemiology Biomarkers and Prevention. 2010 Aug 1;19(8):2013-2022. https://doi.org/10.1158/1055-9965.EPI-10-0163
Miller, Tracie L ; Lipsitz, Stuart R. ; Lopez-Mitnik, Gabriela ; Hinkle, Andrea S. ; Constine, Louis S. ; Adams, M. Jacob ; French, Carol ; Proukou, Cynthia ; Rovitelli, Amy ; Lipshultz, Steven E. / Characteristics and determinants of adiposity in pediatric cancer survivors. In: Cancer Epidemiology Biomarkers and Prevention. 2010 ; Vol. 19, No. 8. pp. 2013-2022.
@article{dd739604c334487290de644b180a6450,
title = "Characteristics and determinants of adiposity in pediatric cancer survivors",
abstract = "Background: Adiposity and the diseases associated with it, including cardiovascular disease, are emerging long-term complications of pediatric cancer survivors. Direct evaluations of adiposity and comparisons to contemporary controls that can differentiate recent trends in obesity from cancer-related treatments and sequelae are limited. Methods: We evaluated demographic, treatment, lifestyle, and endocrine factors at the time of dual-energy X-ray absorptiometry testing in 170 non-Hispanic white survivors and 71 sibling controls, and compared three measures of adiposity [body mass index (BMI), total body fat, and trunk fat]. For the survivors alone, we determined factors independently associated with BMI and body fat. Results: Survivors were at 12 years since diagnosis; 58{\%} had leukemia or lymphoma. BMI did not differ between groups. Among males, body fat was greater in survivors than in controls (25.8{\%} versus 20.7{\%}; P = 0.007), as was trunk fat (26.7{\%} versus 21.3{\%}; P = 0.008). Total or trunk fat did not differ among females. Cholesterol, triglycerides, low-density lipoprotein cholesterol, and television viewing hours were higher among male survivors than in controls. Independent factors associated with higher BMI and total and trunk fat included any cranial radiation and television viewing hours, whereas prior treatment with cyclophosphamide was associated with lower BMI and body fat measures. Conclusions: Compared with siblings, male survivors have greater body fat and metabolic risks. Cranial irradiation and television hours are important risk factors for adiposity in pediatric cancer survivors. Impact: Pediatric cancer survivors should be carefully monitored for cardiovascular risk factors and sedentary lifestyles.",
author = "Miller, {Tracie L} and Lipsitz, {Stuart R.} and Gabriela Lopez-Mitnik and Hinkle, {Andrea S.} and Constine, {Louis S.} and Adams, {M. Jacob} and Carol French and Cynthia Proukou and Amy Rovitelli and Lipshultz, {Steven E}",
year = "2010",
month = "8",
day = "1",
doi = "10.1158/1055-9965.EPI-10-0163",
language = "English",
volume = "19",
pages = "2013--2022",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "8",

}

TY - JOUR

T1 - Characteristics and determinants of adiposity in pediatric cancer survivors

AU - Miller, Tracie L

AU - Lipsitz, Stuart R.

AU - Lopez-Mitnik, Gabriela

AU - Hinkle, Andrea S.

AU - Constine, Louis S.

AU - Adams, M. Jacob

AU - French, Carol

AU - Proukou, Cynthia

AU - Rovitelli, Amy

AU - Lipshultz, Steven E

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Background: Adiposity and the diseases associated with it, including cardiovascular disease, are emerging long-term complications of pediatric cancer survivors. Direct evaluations of adiposity and comparisons to contemporary controls that can differentiate recent trends in obesity from cancer-related treatments and sequelae are limited. Methods: We evaluated demographic, treatment, lifestyle, and endocrine factors at the time of dual-energy X-ray absorptiometry testing in 170 non-Hispanic white survivors and 71 sibling controls, and compared three measures of adiposity [body mass index (BMI), total body fat, and trunk fat]. For the survivors alone, we determined factors independently associated with BMI and body fat. Results: Survivors were at 12 years since diagnosis; 58% had leukemia or lymphoma. BMI did not differ between groups. Among males, body fat was greater in survivors than in controls (25.8% versus 20.7%; P = 0.007), as was trunk fat (26.7% versus 21.3%; P = 0.008). Total or trunk fat did not differ among females. Cholesterol, triglycerides, low-density lipoprotein cholesterol, and television viewing hours were higher among male survivors than in controls. Independent factors associated with higher BMI and total and trunk fat included any cranial radiation and television viewing hours, whereas prior treatment with cyclophosphamide was associated with lower BMI and body fat measures. Conclusions: Compared with siblings, male survivors have greater body fat and metabolic risks. Cranial irradiation and television hours are important risk factors for adiposity in pediatric cancer survivors. Impact: Pediatric cancer survivors should be carefully monitored for cardiovascular risk factors and sedentary lifestyles.

AB - Background: Adiposity and the diseases associated with it, including cardiovascular disease, are emerging long-term complications of pediatric cancer survivors. Direct evaluations of adiposity and comparisons to contemporary controls that can differentiate recent trends in obesity from cancer-related treatments and sequelae are limited. Methods: We evaluated demographic, treatment, lifestyle, and endocrine factors at the time of dual-energy X-ray absorptiometry testing in 170 non-Hispanic white survivors and 71 sibling controls, and compared three measures of adiposity [body mass index (BMI), total body fat, and trunk fat]. For the survivors alone, we determined factors independently associated with BMI and body fat. Results: Survivors were at 12 years since diagnosis; 58% had leukemia or lymphoma. BMI did not differ between groups. Among males, body fat was greater in survivors than in controls (25.8% versus 20.7%; P = 0.007), as was trunk fat (26.7% versus 21.3%; P = 0.008). Total or trunk fat did not differ among females. Cholesterol, triglycerides, low-density lipoprotein cholesterol, and television viewing hours were higher among male survivors than in controls. Independent factors associated with higher BMI and total and trunk fat included any cranial radiation and television viewing hours, whereas prior treatment with cyclophosphamide was associated with lower BMI and body fat measures. Conclusions: Compared with siblings, male survivors have greater body fat and metabolic risks. Cranial irradiation and television hours are important risk factors for adiposity in pediatric cancer survivors. Impact: Pediatric cancer survivors should be carefully monitored for cardiovascular risk factors and sedentary lifestyles.

UR - http://www.scopus.com/inward/record.url?scp=77955462326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955462326&partnerID=8YFLogxK

U2 - 10.1158/1055-9965.EPI-10-0163

DO - 10.1158/1055-9965.EPI-10-0163

M3 - Article

C2 - 20647396

AN - SCOPUS:77955462326

VL - 19

SP - 2013

EP - 2022

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 8

ER -