Chapter 8: Multiple Roles of Glycogen Synthase Kinase-3 in Alzheimer's Disease

Mathieu Lesort, Richard S. Jope

Research output: Chapter in Book/Report/Conference proceedingChapter


One of the most notable developments in research concerning Alzheimer's disease is the solid evidence directly linking glycogen synthase kinase-3 (GSK-3) to most, if not all, of the major mechanisms known to contribute to the neuropathology of the disease. GSK-3 interacts with multiple components of the plaque-producing amyloid system associated with Alzheimer's disease. GSK-3 participates in phosphorylating the microtubule-binding protein tau, which may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. GSK-3 interacts with presenilin and other Alzheimer's disease-associated proteins. GSK-3 has a central role in neuronal plasticity and memory. GSK-3 promotes both inflammation and apoptosis. These many links between GSK-3 and Alzheimer's disease are discussed in this chapter.

Original languageEnglish (US)
Title of host publicationEmerging Drugs and Targets for Alzheimer�s Disease; Volume 1
Subtitle of host publicationBeta-Amyloid, Tau Protein and Glucose Metabolism
EditorsAna Martinez
PublisherRoyal Society of Chemistry
Number of pages20
StatePublished - 2010
Externally publishedYes

Publication series

NameRSC Drug Discovery Series
ISSN (Print)2041-3203
ISSN (Electronic)2041-3211

ASJC Scopus subject areas

  • Drug Discovery


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