Chapter 8: Multiple Roles of Glycogen Synthase Kinase-3 in Alzheimer's Disease

Mathieu Lesort, Richard S. Jope

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

One of the most notable developments in research concerning Alzheimer's disease is the solid evidence directly linking glycogen synthase kinase-3 (GSK-3) to most, if not all, of the major mechanisms known to contribute to the neuropathology of the disease. GSK-3 interacts with multiple components of the plaque-producing amyloid system associated with Alzheimer's disease. GSK-3 participates in phosphorylating the microtubule-binding protein tau, which may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. GSK-3 interacts with presenilin and other Alzheimer's disease-associated proteins. GSK-3 has a central role in neuronal plasticity and memory. GSK-3 promotes both inflammation and apoptosis. These many links between GSK-3 and Alzheimer's disease are discussed in this chapter.

Original languageEnglish (US)
Title of host publicationEmerging Drugs and Targets for Alzheimer�s Disease; Volume 1
Subtitle of host publicationBeta-Amyloid, Tau Protein and Glucose Metabolism
EditorsAna Martinez
PublisherRoyal Society of Chemistry
Pages153-172
Number of pages20
Edition2
DOIs
StatePublished - 2010

Publication series

NameRSC Drug Discovery Series
Number2
Volume2010-January
ISSN (Print)2041-3203
ISSN (Electronic)2041-3211

ASJC Scopus subject areas

  • Drug Discovery

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    Lesort, M., & Jope, R. S. (2010). Chapter 8: Multiple Roles of Glycogen Synthase Kinase-3 in Alzheimer's Disease. In A. Martinez (Ed.), Emerging Drugs and Targets for Alzheimer�s Disease; Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism (2 ed., pp. 153-172). (RSC Drug Discovery Series; Vol. 2010-January, No. 2). Royal Society of Chemistry. https://doi.org/10.1039/9781849731065-00153