Chapter 6 Structure, Function, and Localization of Gβ5-RGS Complexes

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24 Scopus citations


Members of the R7 subfamily of regulator of G protein signaling (RGS) proteins (RGS6, 7, 9, and 11) exist as heterodimers with the G protein beta subunit Gβ5. These protein complexes are only found in neurons and are defined by the presence of three domains: DEP/DHEX, Gβ5/GGL, and RGS. This article summarizes published work in the following areas: (1) the functional significance of structural organization of Gβ5-R7 complexes, (2) regional distribution of Gβ5-R7 in the nervous system and regulation of R7 family expression, (3) subcellular localization of Gβ5-R7 complexes, and (4) novel binding partners of Gβ5-R7 proteins. The review points out some contradictions between observations made by different research groups and highlights the importance of using alternative experimental approaches to obtain conclusive information about Gβ5-R7 function in vivo.

Original languageEnglish (US)
Pages (from-to)157-203
Number of pages47
JournalProgress in Molecular Biology and Translational Science
Issue numberC
StatePublished - 2009

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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