Chapter 22 Pharmacodynamic and Pharmacokinetic Interactions of Psychotropic Drugs with Antiepileptic Drugs

Andres M. Kanner, Barry E. Gidal

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Scopus citations

Abstract

Co-morbid psychiatric disorders are relatively frequent in patients with epilepsy. The prevalence rates of mood and anxiety disorders, psychotic disorders and attention deficit/hyperactivity disorder have been found to be significantly higher in patients with epilepsy than in the general population. While co-morbid psychiatric disorders have frequently been considered as complications of the seizure disorder, there is an increasing body of literature that points to a complex relationship between psychiatric and seizure disorders. Because of this, it is crucial that clinicians consider the presence of co-morbid psychiatric disorders when planning the treatment of patients with epilepsy. Having a clear understanding of the pharmacodynamic and pharmacokinetic interactions between antiepileptic drugs and psychotropic drugs is of the essence to avert unnecessary adverse events and loss of efficacy of psychotropic drugs. This chapter provides a practical review on the use of psychotropic drugs for the treatment of these psychiatric co-morbidities in patients with epilepsy.

Original languageEnglish (US)
Title of host publicationEpilepsy in Women The Scientific Basis for Clinical Management
EditorsBarry Gidal, Cynthia Harden
Pages397-416
Number of pages20
DOIs
StatePublished - Oct 7 2008
Externally publishedYes

Publication series

NameInternational Review of Neurobiology
Volume83
ISSN (Print)0074-7742

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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