Changes in treatment adherence and glycemic control during the transition to adolescence in type 1 diabetes

Joseph R. Rausch, Korey K. Hood, Alan Delamater, Jennifer Shroff Pendley, Jennifer M. Rohan, Grafton Reeves, Lawrence Dolan, Dennis Drotar

Research output: Contribution to journalArticlepeer-review

111 Scopus citations


OBJECTIVE - To test models of unidirectional and bidirectional change between treatment adherence and glycemic control in youth with type 1 diabetes. RESEARCH DESIGN AND METHODS - We conducted a 2-year longitudinal, multisite study of 225 youth with type 1 diabetes recruited at the cusp of adolescence (aged 9-11 years) to describe the mutual influences of glycemic control as measured by HbA 1c and treatment adherence as measured by blood glucose monitoring frequency (BGMF) during the transition to adolescence. RESULTS - HbA 1c increased from 8.2 to 8.6% (P < 0.001) and BGMF decreased from 4.9 to 4.5 checks per day (P < 0.02) during the 2-year period. Changes in the BGMF slope predicted changes in HbA 1c. A change (increase) in HbA 1c was associated with a change (decrease) in BGMF of 1.26 (P < 0.001) after controlling for covariates. CONCLUSIONS - The magnitude of the effect of declining treatment adherence (BGMF) on glycemic control in young adolescents may be even greater than declines observed among older adolescents. BGMF offers a powerful tool for targeted management of glycemic control for type 1 diabetes during the critical transition to adolescence.

Original languageEnglish (US)
Pages (from-to)1219-1224
Number of pages6
JournalDiabetes care
Issue number6
StatePublished - Jun 2012

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing


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